Better Disease Control by Multidrug Regimen in Scabies

Not Applicable

Completed

• Conditions: Scabies
• Interventions: Drug: Permethrin Lotion 5%; Drug: Permethrin Lotion 5% and Oral Ivermectin 200 mcg/kg

• Registration Number: NCT05198947
• Lead Sponsor: B.P. Koirala Institute of Health Sciences

Brief Summary

Scabies is associated with significant discomfort and social taboo. Existing treatment regimen frequently fails due to lack of patient compliance. We compared single use regimen to existing standard repeat application regimen for treatment of scabies.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01
• Primary Completion: 2017-12
• Study Completion: 2018-07
• Study First Submitted: 2021-12-17
• Status Verified: 2022-01
• Study First Submitted QC: 2022-01-05
• Last Update Submitted: 2022-01-05
• Study First Posted: 2022-01-20
• Last Update Posted: 2022-01-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 212

Inclusion Criteria

• Willing patients
• Clinical diagnosis of scabies
• Within the age limits

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Exclusion Criteria

• Unwilling patients
• Patients with severe co-morbidities requiring long term medication
• Pregnant women
• Patients who don't fulfill the age limit criteria

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 1 Permethrin only	Permethrin Lotion 5%	Standard regimen of permethrin 5% topical application to be repeated after 1 week.
Group 2 Permethrin and Ivermectin	Permethrin Lotion 5% and Oral Ivermectin 200 mcg/kg	A combination regimen of permethrin 5% topical application with oral ivermectin 200 mcg/kg given on the single day only

Primary Outcome Measures

Name	Time	Method
Pruritus	1 month	Rate of relief from pruritus assessed using visual analog scale

Secondary Outcome Measures

Name	Time	Method
Skin lesions	1 month	Rate of eradication of skin lesions assessed using physician global assessment scale