NCT00045227CompletedPhase 2
A Pilot Trial of Pox Vector PSA Vaccine With Concurrent Docetaxel Versus Pox Vector Vaccine Followed by Docetaxel in Metastatic Androgen Independent Prostate Cancer
Conditions
Drugs
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Locations
- 1
Study Overview
Brief Summary
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining vaccine therapy with chemotherapy may kill more tumor cells.
PURPOSE: Randomized phase II trial to compare the effectiveness of vaccine therapy with or without docetaxel in treating patients who have metastatic prostate cancer.
Detailed Description
OBJECTIVES:
- Compare the relative change in prostate-specific antigen (PSA)-specific T-cell precursors (CD8) from baseline to day 85 in patients with metastatic androgen-independent prostate cancer treated with a vaccination regimen comprising fowlpox-PSA vaccine, recombinant rV-B7.1 vaccine, recombinant vaccinia-PSA vaccine, and sargramostim (GM-CSF) with or without docetaxel.
- Compare the safety of these regimens in these patients.
- Compare clinical activity of these regimens in these patients.
- Determine the immunologic effects in these patients after additional vaccine/chemotherapy courses.
- Measure CD4 T-cell responses to the vaccine in these patients.
OUTLINE: This is a randomized study. Patients are randomized to 1 of 2 treatment arms after receiving priming vaccinations.
- Priming vaccinations: All patients receive recombinant vaccinia-prostate-specific antigen (PSA) vaccine subcutaneously (SC) and recombinant rV-B7.1 vaccine SC on day 1 and sargramostim (GM-CSF) SC on days 1-4. Patients then receive fowlpox-PSA vaccine (F-PSA) SC on day 15 and GM-CSF SC on days 15-18.
- Arm I: Patients receive docetaxel IV over 30 minutes on days 29, 36, and 43; F-PSA SC on day 30; and GM-CSF SC on days 30-33. Treatment repeats beginning on day 56 for one more course. Patients who do not have disease progression at day 85 receive docetaxel weekly for 3 weeks and F-PSA on day 1 of each course. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive F-PSA SC on days 29 and 57 and GM-CSF SC on days 29-32 and 57-60. Patients who show disease progression after day 85 either radiographically or by rising PSA stop receiving the vaccine and may receive docetaxel weekly for 3 weeks. Chemotherapy repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 28 patients (14 per treatment arm) will be accrued for this study within 9-10 months.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Primary Purpose
- Treatment
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •DISEASE CHARACTERISTICS:
- •Diagnosis of androgen-independent metastatic adenocarcinoma of the prostate, confirmed by 1 of the following:
- •Histologically confirmed disease
- •Pathologically documented disease and clinical course consistent with prostate cancer
- •Castrate levels of testosterone with progressive disease by at least 1 of the following parameters:
- •2 consecutively rising prostate-specific antigen levels, separated by at least 1 week, with at least 1 measurement that is 50% above the nadir reached after the last therapeutic maneuver (must be at least 5 ng/mL)
- •At least 1 new metastatic deposit on technetium Tc 99 bone scintigraphy
- •Progression of soft-tissue metastases by imaging or palpation, as indicated by:
- •Development of new area of malignant disease
- •At least 20% increase in sum of the longest dimension of target lesions
- •Serum testosterone less than 50 ng/dL if no prior surgical castration
- •Luteinizing hormone-releasing hormone therapy must continue
- •HLA-A2 positive
- •No brain metastases
- •PATIENT CHARACTERISTICS:
- •18 and over
- •Performance status
- •Life expectancy
- •More than 6 months
- •Hematopoietic
- •Granulocyte count at least 1,500/mm^3
- •Lymphocyte count at least 500/mm^3
- •Platelet count at least 100,000/mm^3
- •Bilirubin less than 1.5 mg/dL
- •AST and ALT less than 2.5 times upper limit of normal (ULN)
- •Alkaline phosphatase no greater than 2.5 times ULN OR
- •Hepatic alkaline phosphatase fraction less than 2.5 times ULN
- •Creatinine no greater than 1.5 mg/dL OR
- •Creatinine clearance at least 40 mL/min
- •Proteinuria grade 0-1 OR
- •Protein less than 1,000 mg by 24-hour urine collection
- •No hematuria
- •No abnormal sediment unless non-renal
- •Cardiovascular
- •No unstable or newly diagnosed angina pectoris
- •No myocardial infarction within the past 6 months
- •No New York Heart Association class II-IV congestive heart failure
- •No concurrent clinically significant cardiomyopathy requiring treatment
- •Immunologic
- •No prior allergy or untoward reaction to vaccinia virus vaccination
- •No altered immune function, including:
- •Atopic dermatitis
- •Autoimmune disease
- •Autoimmune neutropenia
- •Thrombocytopenia
- •Hemolytic anemia
- •Systemic lupus erythematosus
- •Sjogren's syndrome
- •Scleroderma
- •Myasthenia gravis
- +32 more not shown
Exclusion Criteria
- Not provided
Investigators
Study Sites (1)
Loading locations...
Similar Trials
Unknown
Phase 2
Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal CancerColorectal CancerNCT00027833Herbert Irving Comprehensive Cancer Center
Terminated
Phase 1
Vaccine Therapy and Sargramostim in Treating Patients With Soft Tissue SarcomaSarcomaNCT00027911Columbia University
Completed
Phase 1
Vaccine Therapy in Treating Patients With Resected or Locally Advanced Unresectable Pancreatic CancerPancreatic CancerNCT00008099University of Pittsburgh25
Terminated
Phase 1
Vaccine Therapy in Treating Patients With Metastatic Breast CancerStage IV Breast CancerMale Breast CancerRecurrent Breast CancerNCT00071942National Cancer Institute (NCI)22
Completed
Phase 2
Vaccine Therapy, Interleukin-2, and Sargramostim in Treating Patients With Advanced TumorsUnspecified Adult Solid Tumor, Protocol SpecificBreast CancerLung CancerPancreatic CancerGastric CancerEsophageal CancerNCT00003125Georgetown University24