Evaluation of the influence of physiological anti-coagulant factor, inflammation, and aging on the various anti-coagulation therapies - Evaluation of the influence of physiological anti-coagulant factor, inflammation, and aging on the various anti-coagulation therapies

In contrast to warfarin treatment, DOAC treatment preserves thrombin generation in response to vascular injury and maintains protein C, protein S, and factor VII levels, which could partly explain the lower risk of hemorrhagic complications and thromboembolic events in patients using these anticoagulants. Among DOACs, direct thrombin inhibitors and factor Xa inhibitors may act differently on the coagulation system and this could lead to distinct clinical outcomes.