The effectiveness of curcumin on knee osteoarthritis patients
Phase 2
- Conditions
- Knee arthrosis.Primary gonarthrosis, bilateral
- Registration Number
- IRCT2016100629884N1
- Lead Sponsor
- Vice chancellor for research, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Primary knee osteoarthritis with grade II and III base on Kellgren-Lawrence grading scale; having knee pain at least for six months; age between 45 and 65 years; and having primary osteoarthritis.
Exclusion criteria: Secondary osteoarthritis (due to trauma); knee arthroscopic surgery in less than six months; use of corticosteroids less than six months; history of allergy; coagulation disorders and coronary heart disease; use of medications affecting coagulation process (e.g., warfarin, heparin, clopidogrel, dipyridamole, and aspirin); genu varum, genu valgus, and pes planus patients; and patients with anserine bursitis
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical outcomes including pain, stiffness, and physical function. Timepoint: Before and 6 weeks after intervention. Method of measurement: Western Ontario and Mcmaster Universities Osteoarthritis Index.
- Secondary Outcome Measures
Name Time Method Hepatic effects. Timepoint: After intervention. Method of measurement: Physical examination and levels of liver transaminases.