The Effect of Hemodiafiltration Versus High Flux Dialysis On Free Light Chains Reduction And Its Relation To Albumin Loss.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Free light chain reduction
研究概览
简要总结
Removal of uremic toxins is the main goal of HD, It was improved by using high volume convective technique with high flux (HF) dialyzer. This technique removes medium - large molecular weight solutes giving higher dialysis adequacy and consequently improving the quality of life.
This study will assess the effect of hemodiafiltration (HDF) versus high flux dialysis on free light chains (FLC) reduction as a marker of HD adequacy and its relation to albumin loss using dialyzer effective surface area 2.6m2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prevalent HD patients on regular hemodialysis sessions for >6 months 3 sessions/week of 4 hours duration.
- •Patients with Arterio-venous fistula as dialysis access.
排除标准
- •Patients with hemodialysis catheters.
- •Patients with active inflammation or infection.
- •Decompensated heart failure.
- •Liver Cell Failure ( Child B,C)
- •Patients with known malignancies.
结局指标
主要结局
Free light chain reduction
时间窗: 1 day of hemodialysis session
Measurement of kappa (23KDa) and lambda (45 KDa)free light chains levels, pre and post dialysis session, in patients undergoing high-flux dialysis versus HDF.
次要结局
- Cumulative albumin loss(1 day of hemodialysis session)
研究者
Reem Sultan
Assistant lecturer of Internal Medicine and Nephrology
Ain Shams University