Effects of Diet Interventions on Monocyte Phenotypes in Individuals With Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Effects of diet interventions on monocyte phenotypes
研究概览
简要总结
Subjects with hypertriglyceridemia and metabolic syndrome are being recruited and receive diet interventions with either a high-saturated fat diet or a low-fat high protein diet for 4 days (days 1-4) and a breakfast on day 5. Blood samples are collected on day 1 and day 5 to examine lipid levels and circulating monocyte phenotypes.
详细描述
Subjects with hypertriglyceridemia and metabolic syndrome are being recruited and receive diet interventions with either a high-saturated fat diet or a low-fat high protein diet for 4 days (days 1-4) and a breakfast on day 5. Blood samples are collected on day 1 at fasting state and on day 5 at fasting state and 4 and 6 hours after the breakfast to examine lipid levels and circulating monocyte phenotypes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Obese women and men with metabolic syndrome (MS)
- •Fasting triglyceride (TG) equal to or greater than 150 mg/dl
排除标准
- •<21 years of age
- •Perimenopausal, pregnant or breastfeeding women
- •Current smokers
- •Obvious inflammation or other acute illnesses
- •Obesity due to endocrinologic disorders including polycystic ovary syndrome
- •Partial lipodystrophy
- •Diabetes requiring insulin or >1 oral medication
- •Fasting TG ≥650 mg/dl
- •A history of pancreatitis
- •Myocardial infarction within the past 3 years
- •Any hospitalization within the past 2 months
- •Takes steroids.
结局指标
主要结局
Effects of diet interventions on monocyte phenotypes
时间窗: 2016 to 2020
Monocyte phenotypes
次要结局
未报告次要终点
研究者
Huaizhu Wu
Associate Professor
Baylor College of Medicine