Effect of Transcranial Stimulation Augmented With Mental Imagery in Upper Limb Stroke Rehabilitation: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Fugl Meyers scale for upper limb
研究概览
简要总结
Noninvasive brain stimulation (NIBS) refers to a group of modalities that are used to induce electric currents to and within the brain for diagnostic or therapeutic purposes. Two major types of NIBS techniques are currently in use on humans for clinical and research applications: Transcranial Magnetic Stimulation (TMS) and Transcranial Current Stimulation (tCS). Moreover, the studies evaluating the clinical benefit of mental practice in stroke so far are mostly small feasibility studies, while the few randomized controlled trials reported had relatively small sample sizes. As such, the evidence for mental practice in the treatment of movement disorders following stroke, and other neurological conditions, remains somewhat anecdotal. Purpose of our research is to show the effect of combining brain stimulation and mental imagery on functional recovery of upper limb in stroke.
详细描述
TITLE Effect of Transcranial Stimulation augmented with Mental Imagery in Upper Limb Stroke Rehabilitation: A Randomized Controlled Trial
Mr. Faizan Zaffar Kashoo
Department of Physical Therapy and Health rehabilitation, College of Applied Medical sciences. Majmaah University. KSA
INTRODUCTION
Noninvasive brain stimulation (NIBS) refers to a group of modalities that are used to induce electric currents to and within the brain for diagnostic or therapeutic purposes [1-4]. A growing body of evidence suggests that NIBS techniques may have a promising role in the diagnosis, monitoring, and treatment of a variety of neurological and psychiatric conditions [5-9]. The therapeutic potential of NIBS stems from the capacity to evoke immediate and sustained modulation of neural network activity through alterations in neuronal excitation. The induced neuromodulation can be either excitatory or inhibitory, depending on the polarity, frequency, and duration of the stimulation [2, 10]. Moreover, the ability to induce directional modulation further enhances the therapeutic possibilities of NIBS, as the necessary direction of the brain excitability for recovery varies with different disease conditions [10, 11].
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
transcranial electrical stimulation
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having stroke past 6 months.
排除标准
- •Subarachnoid hemorrhage
- •Prior to stroke resulting in aphasia
- •Brain surgery in the past
- •Epileptic activity in the past 12 months
- •Premorbid (suspected) dementia
- •Premorbid psychiatric disease affecting communication (for example, personality disorder)
- •Excessive use of alcohol or drugs
- •Presence of a cardiac pacemaker
- •Metal implants
研究组 & 干预措施
Group 1
Real Trans-cranial direct stimulation + Mental Imagery
干预措施: Real Transcranial direct stimulation+Mental Imagery (Other)
Group 2
Sham Trans-cranial direct stimulation + Mental imagery
干预措施: Sham Transcranial Direct Stimulation +Mental Imagery (Other)
结局指标
主要结局
Fugl Meyers scale for upper limb
时间窗: 15 minutes
Subjects will be rated on impairment of upper limb. The maximum score of 66 for the upper limb, higher scores imply better outcomes.
次要结局
- Action research Arm Test(15 minutes)
研究者
faizan kashoo, PT
Principal Investigator
Majmaah University