NCT02222519Unknown不适用
Interaction of Statins and Nondepolarizing Muscle Relaxants
Huang-wei LV1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2014年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- plasma myoglobin concentration
研究概览
简要总结
provide evidence for prevention or reduction muscle pain.
详细描述
The purpose of this study is to determine interaction of statins and nondepolarizing muscle relaxant,In order to provide evidence for prevention or reduction muscle pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with American Society of Anesthesiologists physical status I-III
- •Patients taking statins for at least 3 months and those who had never used statins were considered to be eligible
排除标准
- •Orthopedic
- •Spinal surgery
- •Surgery involving extensive muscle manipulation
- •History of liver and kidney failure
- •Neuromuscular disease
- •Susceptibility to or family history of malignant hyperthermia
- •Extensive denervation of skeletal muscle
- •Chronic pain syndromes
- •Taking medications that might interact with the effect of rocuronium or serum myoglobin difficult intubation
研究组 & 干预措施
Statin use group
patients taking statins for at least 3 months
干预措施: Rocuronium (Drug)
non statin use
no history of taking statin
干预措施: Rocuronium (Drug)
结局指标
主要结局
plasma myoglobin concentration
时间窗: 20 minutes after administration
次要结局
- muscle pain(2 and 24 hours postoperatively)
- serum potassium concentration(2 and 24 hours postoperatively)
- plasma creatine phosphokinase concentration(2 and 24 hours postoperatively)
- urine myoglobin and onset plus duration of succinylcholine block(2 and 24 hours postoperatively)
研究者
Huang-wei LV
Professor
First Hospital of China Medical University
研究点 (1)
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