Determining the utility of uraemic toxins in peritoneal dialysis to optimise patient care

Not Applicable

Recruiting

• Conditions: Renal Failure; Peritoneal Dialysis; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12623000531617
• Lead Sponsor: Eastern Health Clinical School

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-19
• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Age greater than or equal to 18
Incident Peritoneal Dialysis (PD) patients (Patient who have been newly started on PD in the last 3 months)

Exclusion Criteria

Patients who are currently pregnant
Patients with Cognitive Impairment or learning differences that are unable to consent
Patient with active malignancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in indoxyl-sulphate level in blood, urine and peritoneal dialysis dialysate <br>[ 12 months post-intervention commencement];Change in p-cresyl sulphate level in blood, urine and peritoneal dialysis dialysate <br>[ 12 months post-intervention commencement]

Secondary Outcome Measures

Name	Time	Method
Any change in patient health related quality of life measure using EQ-5D-5L questionnaire<br>[ 12 months post-intervention commencement];Any change in patient's symptom and mood score using Integrated Palliative Outcome Score (IPOS) renal questionnaire.<br>[ 12 months post-intervention commencement];Any change in physical function assessed using hand grip strength determined using a dynanometer <br><br>[ 12 months post-intervention commencement];Any change in kidney function using serum creatinine (umol/L) and estimated glomerular filtration rate (eGFR) using ml/min/1.73m2 <br><br>[ 12 months post-intervention commencement];Any change in physical function assessed using the timed chair-to-stand test[ 12 months post-intervention commencement];Any change in 24-hour urine output (ml/day) using a 24-hour urine collection bottle with graduated labelling for volume. [ 12 months post-intervention commencement]