Comparative effectiveness of Chloroquine and Vitamin C prophylaxis in household contacts of confirmed COVID-19 patients

Phase 4

• Conditions: Household members of newly diagnosed COVID-19 patients; Household members; COVID-19; Prophylaxis

• Registration Number: TCTR20200404004
• Lead Sponsor: Health Systems Research Institute (HSRI)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-04
• Study Completion: 2020-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Terminated (Halted Prematurely)
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1.Age >18 years old at the time of consent
2.Male or female
3.At least one household member diagnosed with COVID-19 by RT-PCR or serology within the past 7 calendar days
4.Has a negative pregnancy test if the subject is female and pre-menopausal
5.Has provided written consent for participation; written consents from both the subject and a legal guardian

Exclusion Criteria

1.Has a RT-PCR test positive for SARS-CoV2 from pharyngeal or nasopharyngeal swab at baseline (they could be enrolled, and exclude later)
2.Abnormal laboratory >= grade 3
3.Pregnant or planning pregnancy
4.HIV patients receiving PI therapy
5.History of glucose-6-phosphate dehydrogenase (G6PD) deficiency
6.Hypersensitivity to 4-aminoquinoline derivatives
7.Deemed ineligible as determined by the principal investigator or a co-investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Seroconversion of SARS-CoV2 Day 21 Rate of seroconversion

Secondary Outcome Measures

Name	Time	Method
Rate of hospitalization During 21 day Rate of hospitalization