Interventions to Attenuate Cognitive Decline
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 268
- 试验地点
- 2
- 主要终点
- Cognition
研究概览
简要总结
Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engagement, training, or stimulation), but it is not clear which approaches are efficacious. It is also not clear when, along the continuum of normal cognitive aging to mild cognitive impairment (MCI-a transitional stage before dementia onset), it is most efficacious to intervene. This randomized clinical trial will determine the efficacy of a novel cognitive engagement intervention approach (music training) as compared to cognitive stimulation (which will serve as a stringent, active control). Grounded in theory, the central hypothesis is that interventions enhancing central auditory processing (CAP), a strong, longitudinal predictor of MCI and dementia, will improve cognition. Music training is increasingly recognized as a feasible means to attenuate age-related cognitive decline. Prior research and preliminary data suggest that intense piano training enhances CAP and is likely more effective than cognitive stimulation. Correlational studies indicate superior CAP, executive function, and other cognitive abilities for adults with formal music training compared to non-musicians. The specific aims of the study are to examine the efficacy of music training relative to cognitive stimulation (active controls) to improve CAP, cognition, and everyday function among older adults with and without MCI. The efficacy of music training will be established and moderating effects of MCI status will be examined. The proposed study further aims to elucidate the underlying mechanisms of effective cognitive intervention approaches by exploring mediators of training gains. The proposed study is the first phase II randomized trial of music training to enhance older adults' cognition. Mediation analyses will elucidate the underlying mechanisms of intervention effects.
详细描述
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp.
The primary objectives is to examine the efficacy of music training to improve central auditory processing (CAP), cognition, and everyday function among older adults.
The secondary objectives are:
- To examine the moderating effects of mild cognitive impairment (MCI) on music training efficacy.
- To explore mediators of intervention effects.
Design The design is a two arm randomized clinical trial examining the efficacy of music training to improve CAP, cognition, and everyday function in older adults with and without MCI across two time points (baseline and immediate post-test).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 60 years or older
- •willingness to provide informed consent
- •willingness to complete up to 23 study visits including attending in-lab intervention two times a week for a three-month period with the goal of completing 20 sessions.
- •ability to speak and understand English
- •Montreal Cognitive Assessment score of 20 or higher (score 20 to 30 inclusive)
- •intact vision (binocular near visual acuity of 20/50 or better tested with a standard near visual acuity chart)
- •adequate hearing acuity (no greater than a moderate hearing loss [thresholds <70 dB HL] in the mid-frequency range [1000, 2000 Hz] in at least one ear as determined by a standard pure tone hearing evaluation)
- •Music Reading Assessment score of 18 or lower (score 0-18 inclusive)
- •ability to understand study procedures and comply with them for the length of the study in the tester's opinion (and other study personnel opinion who interact with participant, such as the study physician)
排除标准
- •moderate or worse depressive symptoms (Geriatric Depression Scale short form score >=5)
- •previous participation in University of South Florida (USF) Cognitive Aging Lab intervention studies
- •previous participation in 10 or more hours of a computerized cognitive intervention computer programs (e.g., Lumosity, Posit Science Brain Fitness, InSight, or BrainHQ; Lace, CogMed, CogniFit, Happy Neuron, Dakim, DriveSharp or Staying Sharp programs)
- •currently enrolled in another research study
- •planning on being away for two or more weeks during the next five months (recruit later)
- •undergoing chemotherapy or radiation treatment or planning surgeries or other procedures requiring anesthesia within the next five months (recruit later)
- •four or more years of formal music training such as private lessons or group lessons on a specific instrument
- •ability to read music on two or more of the following clefs: Treble clef, Bass clef, Alto clef
- •four or more years of playing any one musical instrument
- •currently practicing or participating in any music activities- such as music performance or music reading or music lessons
- •difficulty and pain in moving hands or fingers, or neuropathy affecting hands, or tremor in either hand
- •self-reported diagnosis of dementia, stroke, serious brain injury or neurological disorder
- •diagnosed by a physician or nurse with a TIA that occurred within the last 18 months
- •inability or unwillingness to give written informed consent at baseline
- •Clinical Dementia Rating Scale score of 1 or greater
- •Clinical diagnosis of dementia or other disorder that in the study physician's opinion would limit the persons ability to participate in the study or benefit from the interventions
结局指标
主要结局
Cognition
时间窗: change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months
A composite of performance on Verbal fluency words generated, Trail Making Test time, and Digit Symbol Coding number correct derived from principal components analyses
次要结局
- Central Auditory Processing(change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months)
- Everyday Function(change from baseline to immediate post intervention at the end of study completion which is a period of about 6 months)
研究者
Jerri D. Edwards
Professor
University of South Florida