Blood sampling after flow-mediated dilatation of the brachial artery: to do or not to do? The Balloon study.

• Conditions: endothelial function; vessel wall function assessement; 10003216

• Registration Number: NL-OMON33710
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

Healthy individuals (males and females) aged 18 years and older

Exclusion Criteria

Smoking, any known risk factors for CVD or any known disorders or disease, chronic use of medication, use of medication prior to the investigation (e.g. NSAIDs), acute infection

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Various parameters of coagulation and inflammation (vWF, platelet p-selectin,<br /><br>platelet activation, aPTT, PT, FVIII:C, D-dimer, prothrombin fragment 1+2,<br /><br>tissue factor, fibrinogen, platelet-monocytcomplex, C-reactive protein, monocyt<br /><br>chemotactic protein, IL-6, IL-8, IL-10, LDL-c, HDL-c, glucose, thrombocyte and<br /><br>leukocyte count, leukocyte differentiation) will be measured at several time<br /><br>points before and after FMD simulation. Does FMD influence these markers of<br /><br>coagulation and inflammation?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>All laboratory parameters will be analysed separately to determine which<br /><br>parameters are influenced by FMD and how long a possible effect lasts.</p><br>