There is an association of signal transduction pathway genes and their interaction with environment factors with antidepressant treatment response in patients of major depressive disorder.

Zhijun Zhang0 个研究点目标入组 411 人开始时间: 2011年1月12日最近更新: 2020年1月13日

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•All recruited patients were between 18-60 years old and met criteria for a diagnosis of major depressive disorder (MDD) according to the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV) . All subjects were new or recently relapsed patients, drug-free for over two weeks and had a baseline score of 18 or over on the 17-item Hamilton Depression Rating Scale (HAMD-17) , having presented depressive symptoms for at least 2 weeks before entry.

•Exclusion criteria included documented history of diagnoses on Axis 1 (including substance abuse, schizophrenia, schizoaffective, bipolar disorder, generalized anxiety disorders, panic disorders or obsessive compulsive disorders) of the DSM-IV, personality disorders, mental retardation, pregnancy, lactation, primary organic disease and other medical illnesses impairing psychiatric evaluation, or a history of electroconvulsive therapy within the previous 8 months. Newly-diagnosed patients were also excluded if they had manic episode in the 12 months following entry.

发起方

Zhijun Zhang