Association of signal transduction pathway genes and their interaction with environment factors with antidepressant treatment response

Not Applicable

Completed

• Conditions: gene and environment factors interaction; major depressive disorder; Mental Health - Depression

• Registration Number: ACTRN12611000040965
• Lead Sponsor: Zhijun Zhang

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 411

Inclusion Criteria

All recruited patients were between 18-60 years old and met criteria for a diagnosis of major depressive disorder (MDD) according to the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV) . All subjects were new or recently relapsed patients, drug-free for over two weeks and had a baseline score of 18 or over on the 17-item Hamilton Depression Rating Scale (HAMD-17) , having presented depressive symptoms for at least 2 weeks before entry.

Exclusion Criteria

Exclusion criteria included documented history of diagnoses on Axis 1 (including substance abuse, schizophrenia, schizoaffective, bipolar disorder, generalized anxiety disorders, panic disorders or obsessive compulsive disorders) of the DSM-IV, personality disorders, mental retardation, pregnancy, lactation, primary organic disease and other medical illnesses impairing psychiatric evaluation, or a history of electroconvulsive therapy within the previous 8 months. Newly-diagnosed patients were also excluded if they had manic episode in the 12 months following entry.

Study & Design

• Study Type: Observational
• Study Design: Not specified