Tranexamic Acid in Lower Limb Arthroplasty Pilot Trial

Phase 4

Completed

• Conditions: Hip or knee joint replacement; Anaesthesiology - Anaesthetics; Surgery - Other surgery; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12613000323729
• Lead Sponsor: Royal Adelaide Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

>45 years of age
Undergoing primary or revision total knee or hip replacement
At least one night inpatient stay

Exclusion Criteria

Poor English language comprehension
Inability to obtain informed consent
Active thrombo-embolic disease such as DVT, PE, or cerebral thrombosis
History of postoperative or spontaneous DVT, pulmonary embolism, spontaneous arterial thrombosis or familial hypercoagulability
End-stage renal failure
Recent haematuria
Contraindication or allergy to TXA
Patients who have received TXA or DDAVP in the last 7 days
Pregnancy
Oral contraceptive (other than low dose Progesterone only)

Study & Design

• Study Type: Interventional
• Study Design: Not specified