Pulmonary and Upper Limb Functions in Duchenne Muscular Dystrophy

Completed

• Conditions: Duchenne Muscular Dystrophy; Upper Limb Function; Respiratory Function Test
• Interventions: Other: The Performance of Upper Limb Questionnaire (PUL)

• Registration Number: NCT03552874
• Lead Sponsor: Hacettepe University

Brief Summary

Although it is known that the functions of pulmonary and upper limb is affected in late stage of Duchenne Muscular Dystrophy (DMD) negatively, the investigators do not have clear information about its early stage. The aim of this study was to investigate the differences in pulmonary and upper limb functions between children with DMD in early stage and healthy peers.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2017-07-31
• Study Completion: 2018-03-31
• Study First Submitted: 2018-05-25
• Status Verified: 2018-06
• Study First Submitted QC: 2018-06-10
• Last Update Submitted: 2018-06-10
• Study First Posted: 2018-06-12
• Last Update Posted: 2018-06-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 47

Inclusion Criteria

children with DMD was;

• age between 5-10 years
• being on treatment with corticosteroids for more than 6 months
• being at Level I according to Brooke Upper and Lower Extremity Classification Systems

Healthy peers;

• age between 5-10 years
• not having any diagnosed disease

Exclusion Criteria

• Children has undergo surgery and disease affect upper extremity or pulmonary function in last six months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy Group	The Performance of Upper Limb Questionnaire (PUL)	Healthy peers
Patient Group	The Performance of Upper Limb Questionnaire (PUL)	Children whose ages between 5-10 years with Duchenne Muscular Dystrophy.

Primary Outcome Measures

Name	Time	Method
Pulmonary Function Test (PFT)	5 minutes	The pulmonary function tests of the participants were evaluated with a spirometry. The child was asked to perform the spirometric tests for three times with maximum effort. The child was motivated before each attempt for stronger and longer expiration.The result of Pulmonary function Test were recorded.
The Performance Upper Limb (PUL)	15 minutes	Upper limb functions of participants were evaluated with The Performance of Upper Limb (PUL) scale. This scale, which was shown to be reliable in DMD, has 22 items in total. It consists of 3 different levels of function: high, mid, and distal. PUL also has four items determining timed performance.