Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions

Not Applicable

Completed

• Conditions: Periodontitis, Chronic; Periodontal Bone Loss; Periodontal Diseases
• Interventions: Procedure: Scaling and root planing; Drug: Toluidine Blue O

• Registration Number: NCT03264118
• Lead Sponsor: University of Sao Paulo

Brief Summary

The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-04-02
• Study First Submitted: 2017-08-24
• Study First Submitted QC: 2017-08-25
• Study First Posted: 2017-08-28
• Primary Completion: 2018-12-22
• Study Completion: 2018-12-22
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-24
• Last Update Posted: 2023-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Clinical diagnosis of class II furcation lesion in mandibular 1st and 2nd molars
• Mandibular 1st and 2nd molars without caries, erosion or abrasion

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Exclusion Criteria

• Smoking habit
• Pregnancy
• Use of antibiotics in the last six months
• Periodontal treatment in the last six months
• Endodontic lesion
• Systemic diseases that impair wound healing

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Scaling and root planing	Decontamination of furcation defect with scaling and root planing only.
Antimicrobial Photodynamic Therapy	Scaling and root planing	Decontamination of furcation defect with scaling and root planing complemented by antimicrobial photodynamic therapy.
Antimicrobial Photodynamic Therapy	Toluidine Blue O	Decontamination of furcation defect with scaling and root planing complemented by antimicrobial photodynamic therapy.

Primary Outcome Measures

Name	Time	Method
Horizontal probing depth	one year	Measured with a periodontal probe (mm). Ideal if 0.
Tomographic Bone filling	One year	Complete filling of furcation defect in tomographic images. Ideal is a radiopaque image similar to neighbor bone.

Secondary Outcome Measures

Name	Time	Method
Clinical Attachment Level	one year	Distance from cemento-enamel junction to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if \< 2 mm.
Probing depth	one year	Distance from gingival margin to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if \< 2 mm.
Bleeding on probing	One year	Visual confirmation of bleeding after probing. Ideal if not bleeding.

Trial Locations

Locations (1)

Bauru School of Dentistry; 🇧🇷 Bauru, Brazil