JPRN-jRCTb040190118
Completed
未知
Therapeutic angiogenesis by cell transplantation with adipose-derived regenerative cells for critical limb ischemia - TACT-ADRC
Murohara Toyoaki0 sites29 target enrollmentFebruary 20, 2020
Conditionscritical limb ischemia
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- critical limb ischemia
- Sponsor
- Murohara Toyoaki
- Enrollment
- 29
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The results of this multicenter clinical trial demonstrate the safety, feasibility, and efficacy of transplanting autologous adipose tissue-derived mesenchymal stem cell progenitor cells for the purpose of antiangiogenic therapy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Target disease: PAD, TAO, and Collagen disease\-associated vasculitis
- •Patients with
- •(1\) 25\<\= Age \<80
- •(2\) CLI (Fontaine III\-IV), who are not candidates for conventional therapies any more, including surgical revascularization
- •(3\) informed consent
Exclusion Criteria
- •Patients with
- •(1\) Insufficient amount of adipose tissue
- •(2\) No informed consent
- •(3\) Expectation of life \< 1 year
- •(4\) A past 5 years or current history of malignant disease
- •(5\) Untreated coronary heart disease or cerebrovascular diseases
- •(6\) Untreated diabetic retinopathy
- •(7\) Laboratory signs of chronic or acute inflammation
- •(8\) Severe liver or kidney dysfunction
- •(9\) Severe anemia or pancytopenia
Outcomes
Primary Outcomes
Not specified
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