Effects of Exercise on Young Adult Women With ACEs: an Integrative Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 2
- 主要终点
- Interleukin-1 receptor agonist
研究概览
简要总结
The process by which the body responds to stressors to maintain homeostasis is called allostasis and is dependent on the integrated function of the nervous, endocrine, and immune systems. ACEs adversely affect these system, cause allostatic load, and can modify development of allostatic systems. However, the central hypothesis is that exercise can reduce allostatic load by positively augmenting function of each of these three systems. No previous studies have examined the effects of structured exercise interventions in individuals with ACEs. The investigators are studying the effects of 8-weeks of structured resistance and aerobic exercise on biomarkers related to nervous, endocrine, immune, and metabolic function and several clinical outcomes in young adult women with ACEs. The specific aims will test several hypotheses, and are as follows: SPECIFIC AIM 1: Conduct a feasibility study to explore whether progressive, structured exercise can help mitigate the adverse physiological effects of stress and trauma early in life. SPECIFIC AIM 2: Determine whether progressive, structured exercise can help improve health-related quality of life, anxiety, and traits like hope, self-efficacy, or self-control, resilience. SPECIFIC AIM 3: Determine whether the type and timing of exposure to ACEs has a significant influence on the severity of psychopathology and long-term physiological response to ACEs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 29 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •provide written and dated informed consent to participate in the study;
- •be willing and able to comply with the protocol;
- •be between the ages of 18 and 29, inclusive;
- •be free from chronic cardiovascular, pulmonary, or musculoskeletal disease as determined by a health history questionnaire;
- •not currently prescribed or taking anti-inflammatory or lipid-lowering medications;
- •have either an ACE score of 0 or 4 or higher;
- •have a BMI between 18.5 and 40.0, inclusive;
- •not enrolled in another clinical trial within thirty days prior to enrollment; and
- •answer no to all questions on the PAR-Q for people aged 15 to 69, which assesses a person's eligibility to engage in exercise without contraindications.
排除标准
- 未提供
结局指标
主要结局
Interleukin-1 receptor agonist
时间窗: 8-weeks
Interleukin-1 receptor agonist concentrations (pg/mL) will be examined from blood samples taken before- and after- the 8-week training or control period.
C-reactive protein
时间窗: 8-weeks
C-reactive protein concentrations (mg/L) will be examined from blood samples taken before- and after- the 8-week training or control period.
Brain-Derived Neurotrophic Factor
时间窗: 8-weeks
Plasma concentrations of brain-derived neurotrophic factor (BDNF; pg/mL), a biomarker of neurogenesis, will be examined from blood samples taken before- and after- the 8-week training or control period.
Skeletal muscle strength
时间窗: 8-weeks
Skeletal muscle strength (Newton meters \[Nm\]) will be determined before- and after- the 8-week training or control period.
Skeletal muscle size
时间窗: 8-weeks
Ultrasound based assessments of skeletal muscle size (cm\^2) will be obtained before- and after- the 8-week training or control period.
Skeletal muscle function
时间窗: 8-weeks
Motor unit behavior will be assessed utilizing surface electromyographic signal decomposition, which will be collected while participants perform submaximal isometric (i.e., static) muscle actions. These signals will be collected before- and after- the 8-week training or control period. To examine motor unit behavior, the relationship between motor unit recruitment threshold versus firing rate will be determined for all detected motor units for an individual subject.
TNF-alpha
时间窗: 8-weeks
TNF-alpha concentrations (pg/mL) will be examined from blood samples taken before- and after- the 8-week training or control period. TNF-alpha is a cytokine involved in systemic inflammation.
Cortisol
时间窗: 8-weeks
Concentrations of salivary cortisol (µg/dL), a stress hormone, will be obtained twice in one day (8 h between samples) before- and after- the 8-week training or control period.
次要结局
- Health-related quality of life(8-weeks)
- Resiliency(8-weeks)
- Monocyte Heterogeneity(8-weeks)
- Hope(8-weeks)
- Anxiety(8-weeks)
- Depression(8-weeks)