Preventing mood and anxiety disorders in youth: a multicentre prevention trial in the high risk offspring of depressed and anxious patients

Completed

• Conditions: depressieve symptomen; anxiety and depression / mood disorder / affective disorders; 10002861

• Registration Number: NL-OMON33876
• Lead Sponsor: Rijksuniversiteit Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 204

Inclusion Criteria

Inclusion criteria (parents): at least one of the biological parents is currently being treated for a depression (MDD, dysthymia) or an anxiety disorder (Social phobia SocP, Agoraphobia AP, Panic disorder PD, Generalized anxiety disorder GAD, Separation anxiety disorder SAD); informed consent.
Inclusion criteria (offspring): age 8-18; being at risk for developing a depression or anxiety disorder, defined as meeting at least 2 of the 3 criteria of the High Risk Index (risk factors: female sex, 2 affected parents, suicide attempt of one of the parents; see Ch. 1) or reporting subthreshold symptoms of anxiety or depression, defined as scoring above the 80th percentile of the RCADS questionnaire (we chose a relatively high cutoff value for the RCADS, to enhance specificity); informed consent.

Exclusion Criteria

Exclusion criteria (both parents): mental retardation; index parent is not fluent in Dutch; severe alcohol or substance use disorder; schizophrenia or other primary psychotic disorder; schizoaffective disorder; bipolar disorder BPD, Obsessive-compulsive disorder OCD, PTSD, only simple phobia SP.
Exclusion criteria (offspring): mental retardation; not speaking Dutch fluently; severe alcohol or substance use disorder; current diagnosis of MDD, dysthymia, SocP, AP, PD, GAD, BPD, PTSD, OCD, SP; previous or current treatment for a DSM-IV psychiatric disorder.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome is the time to onset of depression or anxiety disorder in the<br /><br>offspring. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures include number of days with depression or anxiety,<br /><br>child and parent symptoms, quality of life, and cost-effectiveness. In line<br /><br>with models on aetiology of mood and anxiety disorders as well as mechanisms of<br /><br>change during interventions, we selected possible mediators of treatment<br /><br>outcome, namely attribution style, coping, parent-child interaction and<br /><br>attachment, personality, optimism and self-esteem.</p><br>