Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking

Phase 4

Completed

• Conditions: Anterior MI; Colchicine
• Interventions: Drug: Colchicine 0.5 mg Oral Tablet

• Registration Number: NCT05200052
• Lead Sponsor: Ain Shams University

Brief Summary

Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography longitudinal strain pattern

Detailed Description

The study participants are patients presented with anterior myocardial infarction.

They will be divided into 2 groups. The first group will receive colchicine loading dose of 1mg then 0.5 mg maintenance dose in addition to the standard anti ischemic treatment for 6 months.

The other group will only receive the standard anti ischmic treatment. Speckle tracking echocardiography will be done to all patients to assess left ventricular longitudinal strain pattern.

Study Timeline

• Study First Submitted: 2021-12-20
• Study First Submitted QC: 2022-01-06
• Study First Posted: 2022-01-20
• Study Start: 2022-02-01
• Status Verified: 2022-08
• Primary Completion: 2022-08-01
• Study Completion: 2022-08-01
• Last Update Submitted: 2022-08-19
• Last Update Posted: 2022-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

▪︎Anterior S-T segment elevation myocardial infarction with time of presentation less than 12 hours.

Read More

Exclusion Criteria

• Severe renal impairment.
• Cardiac arrest.
• Cardiogenic shock.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Colchicine 0.5 mg oral tablet	Colchicine 0.5 mg Oral Tablet	100 patients presented with anterior Myocardial infarction undergoing primary Percutaneous coronary intervention will receive colchicine tablet 1mg loading dose and colchicine 0.5 mg maintance dose for 6 months and will do longitudinal strain pattern echocardiography to asses left ventricles systolic function

Primary Outcome Measures

Name	Time	Method
Average of global longitudinal strain pattern	6 months	Assessment of left ventricular longitudinal strain by speckle tracking echocardiography after beforr and after colchicine

Secondary Outcome Measures

Name	Time	Method
Number of mortality during study	6 months	Death from any cause

Trial Locations

Locations (1)

Ain Shams University hospitals; 🇪🇬 Cairo, Egypt