Evaluation of Sticky Bone With or Without EDTA Root Surface Biomodification for Treatment of Gingival Recession: Randomized Controlled Clinical Study
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Kafrelsheikh University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- clinical evaluation of root coverage
Study Overview
Brief Summary
Gingival recession is a common clinical finding in periodontal disease which is frequently associated with esthetic concerns, root hypersensitivity, and root caries. Many surgical therapeutic approaches have been developed to predictably obtain root coverage of gingival recession defects. Injectable PRF (I-PRF) is the liquid form of PRF. I-PRF is a bioactive agent obtained by low-speed centrifugation, and it has the capacity to stimulate tissue regeneration. At high concentrations, PRF may stimulate the secretion of several growth factors and trigger fibroblast migration. I-PRF is generally used in regenerative treatments, with good outcomes. Ethylenediaminetetraaceti acid (EDTA) is a chelating agent that could enhance the attachment of connective tissue to the root surface by exposing collagen and, as a consequence, enhance root coverage. EDTA works at neutral pH, and this property has been reported to preserve adjacent tissue vitality. The present study will be carried out to evaluate the effect of sticky bone with or without EDTA root surface biomodification for treatment of gingival recession.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Care Provider)
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Miller I/II isolated maxillary recession defects.
- •No abrasion, caries, or cervical restorations and presence of identifiable cementoenamel junction (CEJ).
- •No occlusal interferences.
- •Full-mouth plaque index (PI) and gingival index (GI) scores of <
- •Non-smokers.
Exclusion Criteria
- •Pregnant patients
- •Presence of systemic disease or taking medication that interfere with periodontium
Arms & Interventions
sticky bone and EDTA
treatment of gingival recession using sticky bone after root surface biomodification with EDTA
Intervention: Sticky bone and EDTA (Procedure)
Sticky bone
treatment of gingival recession using sticky bone
Intervention: Sticky bone (Procedure)
Outcomes
Primary Outcomes
clinical evaluation of root coverage
Time Frame: 6 months
the percentage of root coverage will be calculated in millimeter
Secondary Outcomes
No secondary outcomes reported
Investigators
Dalia Rasheed Issa
principal invistigator
Kafrelsheikh University