NCT01817673CompletedNot Applicable
Creatine Supplementation on Kidney Function in Resistance-trained Individuals
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Sao Paulo
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- kidney function
Study Overview
Brief Summary
There is a claim that creatine supplementation might affect kidney function, especially in those consuming a high-protein diet. The aim of this study was to investigate the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •participation in recreational resistance training
- •consumption of a high-protein diet (≥ 1.2 g/Kg/d)
Exclusion Criteria
- •vegetarian diet
- •use of creatine supplements in the past 6 months
- •chronic kidney disease
- •use of anabolic steroids.
Arms & Interventions
placebo (dextrose)
Placebo Comparator
20 g/d for 5 d followed by 5 g/d throughout the trial
Intervention: placebo (Dietary Supplement)
creatine
Experimental
20 g/d for 5 d followed by 5 g/d throughout the trial
Intervention: creatine (Dietary Supplement)
Outcomes
Primary Outcomes
kidney function
Time Frame: 3 months
as assessed by 51Cr-EDTA clearance
Secondary Outcomes
- proteinuria(3 months)
- albuminuria(3 months)
- serum urea(3 months)
- serum creatinine(3 months)
Investigators
Bruno Gualano
Professor
University of Sao Paulo
Study Sites (1)
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