Study on the Antiaging Effect of Chinese Herb Drink

Not Applicable

Completed

• Conditions: Gynecological Disorders
• Interventions: Other: Si-Wu-Tang (SWT); Other: placebo

• Registration Number: NCT02634242
• Lead Sponsor: Chung Shan Medical University

Brief Summary

The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.

Detailed Description

Background: Si-Wu-Tang (SWT) is a well-known traditional Chinese medicine (TCM) and widely used for treating various gynecological disorders. The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.

Methods: Sixty healthy voluntary subjects were recruited and assigned into two groups, who drank 125 mL of placebo (n=30) or SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. During the initial, 3rd, 6th, 10th, and 13th months anthropometric measurements were performed as well as fasting blood samples were drawn for various biochemical assays. Abdominal ultrasonic and skin examination were performed at the initial, 6th and 13th months.

Study Timeline

• Study Start: 2008-04
• Primary Completion: 2009-04
• Study Completion: 2009-04
• Status Verified: 2015-12
• Study First Submitted: 2015-12-08
• Study First Submitted QC: 2015-12-15
• Last Update Submitted: 2015-12-15
• Study First Posted: 2015-12-18
• Last Update Posted: 2015-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• healthy adults

Exclusion Criteria

• exclusion criteria were history of smoking, alcoholism
• pregnant or lactating women,
• chronic diseases, hepatic or renal dysfunction.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Si-Wu-Tang (SWT)	placebo	Subjects are recommended to drink 125 mL of SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between.
Si-Wu-Tang (SWT)	Si-Wu-Tang (SWT)	Subjects are recommended to drink 125 mL of SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between.
placebo	Si-Wu-Tang (SWT)	Subjects are recommended to drink 125 mL of Placebo (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between.
placebo	placebo	Subjects are recommended to drink 125 mL of Placebo (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between.

Primary Outcome Measures

Name	Time	Method
Total thiobarbituric acid reactive substances (TBARS)	6 months

Secondary Outcome Measures

Name	Time	Method
Glutathione content (GSH)	6 months
Total antioxidant capacity (TEAC)activities.	6 months
Glutamic pyruvic transaminase (GPT)	6 months
Superoxide dismutase (SOD) activity	6 months
GPx and glutathione reductase (GR) activity	6 months
Catalase	6 months
Glutamic oxaloacetic transaminase (GOT)	6 months