Thyroid Profiles in Patients With Acute Illness

Withdrawn

• Conditions: Thyroid Dysfunction; Acute Illness
• Interventions: Other: Performing blood thyroid test (TSH, FT4, FT3)

• Registration Number: NCT05980923
• Lead Sponsor: Jordan Collaborating Cardiology Group

Brief Summary

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

Detailed Description

Recently, there has been a growing body of evidence that subclinical thyroid dysfunction as a contributor to the increase of cardiovascular events. Elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine (FT4) and free triiodothyronine (FT3) levels have been associated with worse heart failure and dyslipidemia. Furthermore, higher risk of atrial fibrillation has been linked tp thyroid abnormalities in these patients.

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients. This study aimed at evaluating the prevalence of thyroid function abnormalities in patients admitted to hospital with acute illness and their temporal changes and impact on mortality during hospitalization and at 1 year. Serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (ATF group) will be compared to those with normal thyroid function (NTF group). Short and long term survival of both groups were compares as well.

Study Timeline

• Study First Submitted: 2023-07-20
• Study First Submitted QC: 2023-08-07
• Study First Posted: 2023-08-08
• Study Start: 2023-10-15
• Primary Completion: 2025-01-15
• Study Completion: 2025-01-30
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-23
• Last Update Posted: 2025-02-25

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Hospital admission
• Adults aged 18 years and above
• Willing to sign an informed consent
• Diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.

Exclusion Criteria

• Age less than 18 years.
• Refusal to sign consent.
• Admission for a reason not classified as acute illness.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
GROUP 1: Acute illness and abnormal thyroid function	Performing blood thyroid test (TSH, FT4, FT3)	Patients admitted to the hospital with acute illness and found to have thyroid function abnormalities.
GROUP 2: Acute illness and normal thyroid function	Performing blood thyroid test (TSH, FT4, FT3)	Patients admitted to the hospital with acute illness and found to have normal thyroid function.

Primary Outcome Measures

Name	Time	Method
In hospital mortality	From time of study entry until the date of death from any cause, assessed up to 2 weeks.	All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function during the patients hospital stay..

Secondary Outcome Measures

Name	Time	Method
6-month mortality rate	From date of study entry until the date of death from any cause, assessed up to two weeks.	All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function at 6 months.

Trial Locations

Locations (1)

Istishari Hospital; 🇯🇴 Amman, Jordan