Rôle Pronostique Des métabolismes du Stress Oxydatif et du Fer Dans Les Leucémies Aiguës Myéloblastiques
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- overall survival Event-free survival Response to induction chemotherapy, overalll survival, event-free survival
研究概览
简要总结
In this study, the investigators study the prognostic role of oxidative stress metabolism and iron in Acute myeloid leukemia.
详细描述
Primary goal of this study is to Evaluate the characteristics of regulatory networks of iron and redox balance in leukemic cells, to study the correlations between the prognosis of AML patients (in terms of response to induction chemotherapy and survival i) and metabolism of these markers. Secondary ones areto assess the impact of induction therapy on markers of oxidative stress and to correlate biological iron and redox metabolism with the molecular status of patients (eg Flt3/IDH/CEBPA/NPM...).
Eligibility criteria are patients at diagnostic of de novo acute myeloid leukemia (promyelocytic excluded) aged from 18 to 100 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •de novo acute myeloid leukemic patient from 18 years to 99 years at diagnosis
排除标准
- •age under 18 years promelocytic leukemia secondary leukemia
结局指标
主要结局
overall survival Event-free survival Response to induction chemotherapy, overalll survival, event-free survival
时间窗: five years after the inclusion
次要结局
未报告次要终点