Metabolism Des LAM

• Conditions: Iron; Diagnosis; Acute Myeloid Leukemia; Oxydative Stress

• Registration Number: NCT02176109
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

In this study, the investigators study the prognostic role of oxidative stress metabolism and iron in Acute myeloid leukemia.

Detailed Description

Primary goal of this study is to Evaluate the characteristics of regulatory networks of iron and redox balance in leukemic cells, to study the correlations between the prognosis of AML patients (in terms of response to induction chemotherapy and survival i) and metabolism of these markers. Secondary ones areto assess the impact of induction therapy on markers of oxidative stress and to correlate biological iron and redox metabolism with the molecular status of patients (eg Flt3/IDH/CEBPA/NPM...).

Eligibility criteria are patients at diagnostic of de novo acute myeloid leukemia (promyelocytic excluded) aged from 18 to 100 years.

Study Timeline

• Status Verified: 2013-06
• Study Start: 2013-06
• Study First Submitted: 2014-06-24
• Study First Submitted QC: 2014-06-25
• Last Update Submitted: 2014-06-25
• Study First Posted: 2014-06-26
• Last Update Posted: 2014-06-26
• Primary Completion: 2015-06
• Study Completion: 2018-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

de novo acute myeloid leukemic patient from 18 years to 99 years at diagnosis

Exclusion Criteria

age under 18 years promelocytic leukemia secondary leukemia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
overall survival Event-free survival Response to induction chemotherapy, overalll survival, event-free survival	five years after the inclusion

Trial Locations

Locations (1)

University Hospital Grenoble; 🇫🇷 Grenoble, Isere, France