Assessement of the effects of coffee main constituents in none- alcoholic fatty liver patients with type 2 diabetes
- Conditions
- AFLD.(Nonalcoholic fatty liver disease (NAFLD
- Registration Number
- IRCT201707024010N21
- Lead Sponsor
- IMAD
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria:
Patient diagnosed with type 2 diabetes based on American Diabetes Association (ADA) definition or who only take oral antidiabetic drug.
CAPscore >263
Taking any kind of antibiotics two weeks before recruitment;
History of alcohol consumption ;
pregnancy or lactation;
Professional athletes;
Other liver disease (viral/etc);
High dose synthetic estrogens, methotrexate , amiodarone, steroids, chloroquine, immunosuppressive drugs;
A history of Cardiovascular disease;
Renal disease, Celiac disease, Cirrhosis;
History of Upper Gastrointestinal surgery ;
A history of hypothyroidism or Cushing's syndrome;
History of drug dependence;
Body mass index (BMI) =35 kg/m2;
A restrictive diet or weight change = 5 kg during the 3 months prior to study;
Any change in treatment with oral hypoglycemic; anti hypertensive and antilipid agents during the study;
Use of weight loss medications
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method iver fibrosis. Timepoint: Before and 24 weekes after the intervention. Method of measurement: fiberscan.;Glucose. Timepoint: Before and 24 weekes after the intervention. Method of measurement: mg/dl.;Weight. Timepoint: Before and 24 weekes after the intervention. Method of measurement: kg.;AST. Timepoint: Before and 24 weekes after the intervention. Method of measurement: U/L.;GGT. Timepoint: Before and 24 weekes after the intervention. Method of measurement: U/L.;ALT. Timepoint: Before and 24 weekes after the intervention. Method of measurement: U/L.;Liver Steatosis. Timepoint: Before and 6 weekes after the intervention. Method of measurement: ultrasonography.
- Secondary Outcome Measures
Name Time Method