Tylenol Levels in Bariatric Patients

Completed

Brief Summary: The current study is designed to measure and evaluate the pharmacokinetic profiling of acetaminophen in the young obese patient population.

Detailed Description: This will be a descriptive study carried out by study staff from the anesthesiology department. The patient population will include obese patients scheduled for robot-assisted or laparoscopic bariatric surgery. There will be no change in our usual anesthetic care for these patients. Volume of distribution and elimination half-life of acetaminophen in serum samples are the primary measurements of the study. If detected, a significant reduction in opioid requirements may lead to improved patient satisfaction and decreased opiate side effects.

Recruitment & Eligibility

Inclusion Criteria

Patients older than 12, but younger than 21 years of age undergoing robotic assisted or laparoscopic bariatric surgery
American Society of Anesthesiologists Physical Status Classification System (ASA) I, II or III
Parent/guardian willing and able to give consent
Patient willing to give assent, or consent
Patients that are otherwise healthy at the discretion of the study staff
Patients with BMI >95th percentile

Exclusion Criteria

Patients with severe right heart failure or severe asthma
Patients with deficient hepatic function that can affect drug metabolism
Systemic steroid use within the last 3 months
Patients who have taken acetaminophen containing medications within 24 hours of surgery date
Patients younger than 12, but older than 21 years of age undergoing robotic assisted or laparoscopic bariatric surgery
Patients having other procedures in addition to robotic assisted or laparoscopic bariatric surgery
American Society of Anesthesiologists Physical Status Classification System (ASA) IV and above
Females testing positive for pregnancy
Parent/guardian not willing and able to give assent, or consent
Patient not willing to give assent, or consent
Patients with BMI < 95th percentile

Primary Outcome Measures

Name	Time	Method
Intra- and Post-operative Serum Concentrations	15-20 minutes; 30-40 minutes; 50-70 minutes; 80-100 minutes; 2 Hours, 4 Hours; 8 Hours; and 12-Hours Post-IV acetaminophen administration	To determine whether adequate serum concentration of acetaminophen is achieved.

Secondary Outcome Measures