Dose Response Oxidation of a Sweet-corn Derived Polysaccharide (PhytoSpherix) During Exercise in Endurance Trained Athletes
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Oxidation of PhytoSpherixat
研究概览
简要总结
PhytoSpherix (Phx) is an all-natural, edible polysaccharide extracted from sweet corn. This carbohydrate is the major muscle fuel for intense exercise and its stores are quite small such that one can run out of it during a single exercise bout. Therefore, Phx should provide significant exercise fuel if consumed during exercise. As a result its intake could enhance intense exercise performance by providing additional fuel. This experiment Will investigate the effects of 4 different dosages of Phx consumed throughout a prolonged exercise bout on carbohydrate and fat utilization as well as its oxidation rate and perception of effort during prolonged intense exercise in trained cyclists. Muscle and liver carbohydrate stores will be examined using a non-invasive ultrasound technique.
详细描述
Carbohydrate (CHO) is one of the main substrate oxidized during moderate-to-high intensity, endurance-type exercise. It's been shown that CHO feeding during exercise enhances endurance performance and capacity, attributed mainly to the facilitation of greater rates of exogenous CHO oxidation, prevention of hypoglycaemia and sparing of muscle glycogen. Previous studies based on supplementation of glucose during 180 min. of cycling exercise have reported a maximal rate of exogenous CHO oxidation to be about 1 g/min. Other studies have shown that CHO oxidation rates can reach peak values of about 1.3 g/min when a combination of fructose and glucose is ingested at a rate of 1.8 g/min. The limitation in uptake and oxidation of a single CHO source is attributed to its intestinal transporter saturation such that when multiple CHO source is used the uptake and oxidation rate is increased to a greater extent. Currently there is no information regarding Phx uptake or oxidation rate as a CHO source during exercise. Also, it is important to investigate whether Phx as a CHO sport drink can increase performance by sparing muscle and liver glycogen during exercise. Therefore, the objective of this experiment is to measure dose response of Phx oxidation rate during prolonged cycling exercise and its effect on muscle and liver glycogen levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male endurance trained athletes with >2 y cycling experience; about 2 h/day
排除标准
- •Unhealthy athletes, smokers
研究组 & 干预措施
Endurance trained male cyclists
8 male endurance trained male cyclist will consume varying amounts (0, 1, 1.5 and 2 g/min) of PhytoSpherix (sweet-corn derived sugar) during a 150 min . cycling exercise
干预措施: Use of PhytoSpherix at 0 g/min (Dietary Supplement)
Endurance trained male cyclists
8 male endurance trained male cyclist will consume varying amounts (0, 1, 1.5 and 2 g/min) of PhytoSpherix (sweet-corn derived sugar) during a 150 min . cycling exercise
干预措施: Use of PhytoSpherix at 1 g/min (Dietary Supplement)
Endurance trained male cyclists
8 male endurance trained male cyclist will consume varying amounts (0, 1, 1.5 and 2 g/min) of PhytoSpherix (sweet-corn derived sugar) during a 150 min . cycling exercise
干预措施: Use of PhytoSpherix at 1.5 g/min (Dietary Supplement)
Endurance trained male cyclists
8 male endurance trained male cyclist will consume varying amounts (0, 1, 1.5 and 2 g/min) of PhytoSpherix (sweet-corn derived sugar) during a 150 min . cycling exercise
干预措施: Use of PhytoSpherix at 2 g/min (Dietary Supplement)
Endurance trained male cyclists
8 male endurance trained male cyclist will consume varying amounts (0, 1, 1.5 and 2 g/min) of PhytoSpherix (sweet-corn derived sugar) during a 150 min . cycling exercise
干预措施: Cycling exercise (Behavioral)
结局指标
主要结局
Oxidation of PhytoSpherixat
时间窗: 0, 15, 30, 45, 60, 75, 90, 135, 150 min from the beginning of the exercise session
Breath samples will be taken starting at 0, 15, 30, 45, 60, 75, 90, 135, up to 150 min from the beginning of the exercise session to measure change in oxidation of PhytoSpherix
Noninvasive ultrasound measure of glycogen in Vastus lateralis, rectus femoris and liver
时间窗: 10 min before and 10 min after the 150 min exercise session
Change in muscle and liver glycogen will be measured 10 min before and 10 min after exercise session. When muscle and liver glycogen content is high, the ultrasound image is hypoechoic (dark), and with glycogen depletion and water loss, the image is hyperchoic (brighter).Three ultrasound measurements at each site will be made by a trained technician using a 12 MHz linear transducer and a standard diagnostic high resolution GE LOGIQ-e ultrasound machine (GE Healthcare, Milwaukee, WI). After calculating statistics on the color bar to determine the general brightness settings of the machine, images will be pre-processed and segmented to isolate the muscle area under analysis using a center crop within the muscle section 25 mm from the top muscle sheath. Comparing these results will help better understand the effect of supplementation of Phx at different rates on any changes in glycogen stores of muscle and liver.
次要结局
- Respiratory exchange ratio(At 0, 15, 30, 45, 60, 75, 90, 135, 150 min from the beginning of the exercise session)
- blood glucose concentration(0, 15, 30, 45, 60, 75, 90, 135, 150 min from the beginning of the exercise session)
- blood lactate concentration(0, 15, 30, 45, 60, 75, 90, 135, 150 min from the beginning of the exercise session)
- rate of perceived exertion(At 0, 15, 30, 45, 60, 75, 90, 135, 150 min from the beginning of the exercise session)
- questionnaire to rate possible gastrointestinal (GI) problems(At 30, 60, 90, 120 and 150 min from the beginning of the exercise session)
研究者
Peter Lemon
Professor
University of Western Ontario, Canada