The Impact of Slow, Continuous Infusion of Sodium Chloride or Glucose Solution on Diuresis and Urine Composition During Decongestion of Acute Heart Failure Patients
Overview
- Phase
- Phase 3
- Intervention
- Furosemide intravenous infusion
- Conditions
- Acute Heart Failure
- Sponsor
- Wroclaw Medical University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Urine volume change at individual timepoints during second day of the procedure.
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart failure.
Investigators
Gracjan Iwanek
Medical Doctor
Wroclaw Medical University
Eligibility Criteria
Inclusion Criteria
- •patients \>18 years old who sign the informed consent
- •the primary cause of hospitalization is Acute Heart Failure with a need for intravenous Furosemide
- •the start of the study within 24h of hospital admission
Exclusion Criteria
- •need for inotropic support
- •end stage renal disease on dialysis
- •serum sodium \> 148mmol/l or \< 130 mmol/l.
Arms & Interventions
0.9 % Sodium Chloride solution
Patients receiving an intravenous infusion of 0.9% NaCl
Intervention: Furosemide intravenous infusion
0.9 % Sodium Chloride solution
Patients receiving an intravenous infusion of 0.9% NaCl
Intervention: Continous intravenous infusion of 0.9% Sodium Chloride solution
5% Glucose solution
Patients receiving an intravenous infusion of 5% glucose
Intervention: Furosemide intravenous infusion
5% Glucose solution
Patients receiving an intravenous infusion of 5% glucose
Intervention: Continous intravenous infusion of 5% Glucose solution
Outcomes
Primary Outcomes
Urine volume change at individual timepoints during second day of the procedure.
Time Frame: 48 hours
Comparison of urine volume between the groups at individual timepoints during the second day of the procedure.
Urine volume change at individual timepoints during first day of the procedure.
Time Frame: 24 hours
Comparison of urine volume between the groups at individual timepoints during the first day of the procedure.
Total dose of furosemide.
Time Frame: 48 hours
Comparison of the total dose of furosemide between the groups at hours.
Urine composition at individual time points.
Time Frame: 72 hours
Comparison of urine composition (urinary sodium and urinary chloride) between the groups and its change during 72h
Cumulative urine output at 24 hours.
Time Frame: 24 hours
Comparison of cumulative urine output between the groups at 24 hours.
Cumulative urine output at hours.
Time Frame: 48 hours
Comparison of cumulative urine output between the groups at 48 hours.
Secondary Outcomes
- Total time on intravenous furosemide.(3 months)
- Renin-Angiotensin-Aldosterone system activity.(48 hours)
- Heart Failure rehospitalization(30 days)