Brain Connectivity and Mindfulness Training in Youth With Bipolar Disorder NOS
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Stanford University
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Dorsal Medial Network functional connectivity
Study Overview
Brief Summary
The investigators propose to study 30 adolescents with bipolar disorder, not otherwise specified (BD NOS) and a family history of Bipolar I Disorder (BD) at baseline with rs-fMRI (functional magnetic resonance imaging) and functional connectivity (FC) analyses and compare data with previously acquired rs-fMRI and FC data from 20 age- and gender-matched healthy controls (HC). Subjects will then undergo a 12-week Mindfulness based stress reduction- teen (MBSR-T) intervention and be reassessed and rescanned. The intervention and scanning will take place in groups of 6-8 subjects/group/year over the 4 years. This proposal will be a natural progression of past research, while extending the investigators' expertise to include advanced FC analyses and mindfulness based interventions in youth with mood dysregulation. The investigators will also integrate trainees into the imaging and therapy components of this study, furthering our mission of mentoring the next generation of innovative researchers who will push the field forward.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 13 Years to 17 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Ages 13-17
- •Diagnosed with BD-NOS
- •First or second degree relative diagnosed with bipolar I or II
Exclusion Criteria
- •Not English speaking
- •For those who are to participate in the MRI scan, having any metal in the body or movement disorders will be an exclusionary factor
Arms & Interventions
Mindfulness group
Participation in a 12 week mindfulness therapy group.
Intervention: Mindfulness Based Stress Reduction for Teens Group (Behavioral)
Outcomes
Primary Outcomes
Dorsal Medial Network functional connectivity
Time Frame: 12 weeks
(1) Use ICA to compare DMN in subjects with BD NOS to healthy controls (HC)
Functional connectivity of sgACC with thalamus, VMPFC, and amygdala
Time Frame: 12 weeks
(2) Investigate level of FC of the sgACC with thalamus, VMPFC, amygdala, and FC of pCing with amygdala/hippocampus, comparing subjects to HC.
Secondary Outcomes
- Degree of Mindfulness(12 weeks)