Association Between Toll Like Receptor- 7 Gene Polymorphism and Alopecia Areata
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Genotype and Allele Frequency Distribution of TLR7 rs3853839
研究概览
简要总结
Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses. The rs3853839 polymorphism of the TLR7 gene has been implicated in immune-mediated diseases. This study aims to evaluate the association between TLR7 rs3853839 polymorphism and susceptibility to alopecia areata, and to assess its correlation with disease severity measured by the Severity of Alopecia Tool (SALT) score.
________________________________________
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of alopecia areata
- •Age ≥ 18 years
- •Both genders
- •Provision of written informed consent
- •Inclusion Criteria (Controls):
- •Apparently healthy individuals
- •No personal or family history of autoimmune disease
- •Age- and sex-matched to patient group
- •Provision of written informed consent
排除标准
- •Presence of other autoimmune or inflammatory disorders
- •Current systemic immunosuppressive therapy
- •Pregnancy or lactation
- •Refusal to participate
- •Exclusion Criteria:
研究组 & 干预措施
Alopecia Areata Patients
Sixty patients diagnosed clinically with alopecia areata. Peripheral blood samples will be collected for DNA extraction and genotyping of TLR7 rs3853839 polymorphism. Disease severity will be assessed using the SALT score.
Healthy Controls
Sixty age- and sex-matched healthy individuals without autoimmune disease. Peripheral blood samples will be collected for DNA extraction and genotyping of TLR7 rs3853839 polymorphism.
结局指标
主要结局
Genotype and Allele Frequency Distribution of TLR7 rs3853839
时间窗: Baseline
Comparison of genotype and allele frequencies of TLR7 rs3853839 polymorphism between alopecia areata patients and healthy controls.
次要结局
- Association Between TLR7 rs3853839 Polymorphism and Disease Severity(Baseline)
研究者
karem Taha ibrahim khalil
Assistant professor
Benha University