Fluoride Availability in Saliva After Use of NaF or MFP Toothpastes
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Area under the curve of salivary fluoride concentration versus time after brushing with fluoride toothpastes
研究概览
简要总结
Considering the widespread use of sodium fluoride (NaF) and monofluorophosphate (MFP) based toothpastes, the present study aim to evaluate F availability in saliva after use of the top-selling Brazilian toothpastes. In a blind, crossover clinical trial study, volunteers will brush their teeth with one of the following toothpastes: 1) non-fluoride toothpaste (negative control group); 2) NaF/silica based toothpaste 3)MFP/calcium carbonate based toothpaste. After brushing, a rinse with purified water will be performed. Unstimulated saliva will be collected before and up to 60 min after brushing. Ionic fluoride and total soluble fluoride (corresponding to the sum of fluoride as ion and as MFP) will be determined after acid treatment of salivary samples to hydrolyze MFP. Fluoride will be determined using an ion selective electrode.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Good general health
- •Good oral health
- •Normal salivary flow rate
排除标准
- •Use of systemic drugs that reduce salivary flow rate
研究组 & 干预措施
Non-fluoride toothpaste
干预措施: Toothpaste (Drug)
NaF/SiO2 toothpaste
干预措施: Toothpaste (Drug)
MFP/CaCO3 toothpaste
干预措施: Toothpaste (Drug)
结局指标
主要结局
Area under the curve of salivary fluoride concentration versus time after brushing with fluoride toothpastes
时间窗: 60 minutes
次要结局
- Percentage of MFP hydrolyzed in saliva as a function of time(60 minutes)
研究者
Livia Maria Andaló Tenuta
Assistant Professor, Biochemistry and Cariology
University of Campinas, Brazil