Cognitive Behavioral Stress Management (CBSM) & Prostate Cancer

Change in Perceived Stress Management Abilities as measured by the Measure of Current Status Questionnaire

时间窗: Baseline, up to 18 months

The Measure of Current Status questionnaire is a 23-item questionnaire each scored on a range of 0-4. The total score ranges from 0-92 with the higher score corresponding to greater perceived abilities.

Change in immune cell percentage

时间窗: Baseline, up to 18 months

Immune cell percentage (including T-cell (Cluster of Differentiation (CD) 3+) and T-helper cells (CD 3+ CD 4+) will be evaluated from blood samples. Both values evaluated in count per cubic millimeter over total cell count per cubic millimeter.

Change in ratio of natural killer cell cytotoxicity as captured by Lytic Index

时间窗: Baseline, up to 18 months

Natural killer cell (CD56+CD3-) cytotoxicity is evaluated from blood samples. Cells are stimulated through exposure to a reactive cell line and quantified as the ratio of responsive to unresponsive cells required to kill 10% of the target cell line.

Change in post-traumatic event perceptions as measured by the Benefit Finding Scale questionnaire

时间窗: Baseline, up to 18 months

The Benefit Finding Scale questionnaire is a 17-item measure capturing perception of a traumatic event (e.g., cancer diagnosis for participants) with each item scored on a scale of 1 to 5. The total score ranges from 17-85 with the higher score corresponding to greater perceived benefit.

Change in optimism as measured by the Life Orientation Test - Revised questionnaire

时间窗: Baseline, up to 18 months

The Life Orientation Test - Revised questionnaire measures participant's optimism. The total score ranges from 0-24 with the higher score corresponding to greater levels of optimism.

Change in count of natural killer cell cytotoxicity as captured by Kinetic Lytic Index

时间窗: Baseline, up to 18 months

Natural killer cell (CD56+CD3-) cytotoxicity is evaluated from blood samples. Cells are stimulated through exposure to a reactive cell line and incubated for four hours total. Kinetic lytic index is quantified as the count of targeted cells killed during incubation. An average count of these cells will be calculated.

Change in natural killer cell percentage

时间窗: Baseline, up to 18 months

Natural killer cell (CD56+CD3-) percentage is evaluated from blood samples. Values are evaluated in count per cubic millimeter over total cell count per cubic millimeter.

Change in immune cell count

时间窗: Baseline, up to 18 months

Immune cell count (including T-cell (Cluster of Differentiation (CD) 3+) and T-helper cells (CD 3+ CD 4+) will be evaluated from blood samples. Both values will be evaluated in count per cubic millimeter.

Change in natural killer cell count

时间窗: Baseline, up to 18 months

Natural killer cell (CD56+CD3-) count is evaluated from blood samples. Values are evaluated in count per cubic millimeter.

Change in natural killer cell cytotoxicity as captured by activity percentage

时间窗: Baseline, up to 18 months

Natural killer cell (CD56+CD3-) cytotoxicity is evaluated from blood samples. Cells are stimulated through exposure to a reactive cell line and the percentage of cells active are counted and divided by total cells present per cubic millimeter.