Electronic Cigarettes and Reactivity to Smoking Cues
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 125
- 试验地点
- 2
- 主要终点
- Reduction in Cue Reactivity
研究概览
简要总结
The purpose of this study is to determine whether electronic cigarettes can reduce reactivity to smoking-related cues.
详细描述
Tobacco-related illness causes over 5 million deaths per year in the developed world, and most currently available smoking cessation treatments do not effectively enhance long-term cessation outcomes. Reactivity to smoking cues is one factor associated with relapse vulnerability, which is untreated by cessation aids such as NRT. Combining treatments, which ameliorate both pharmacological nicotine withdrawal and reduce smoking cue reactivity, may enhance smoking cessation success. During this study we will test whether combining NRT with non-nicotine containing electronic cigarettes (e-cigarettes) effectively reduces reactivity to smoking cues. The only source of nicotine participants will receive during the study will come from NRT. We will use e-cigarettes that provide no nicotine, yet may provide a similar experience to smoking as e-cigarettes taste and feel similar to a regular cigarette. However, since nicotine delivery is not associated with the act of smoking the reinforcing effects associated with smoking behavior may be reduced. Reactivity to smoking cues will be assessed using a battery of measures including: self-report, behavioral, and neuroimaging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Provide written informed consent.
- •Be aged 18-
- •Report smoking cigarettes daily in the past 6 months.
- •Have expired breath CO indicative of regular smoking.
- •Have a score greater than 0 on the FTND.
- •Be willing to use Nicotine Replacement Therapy (NRT) and the e-cigarette for a period of 2 to 3 weeks.
- •Speak and read English.
- •Pass an MRI safety screen and meet inclusion criteria for MRI scans.
排除标准
- •Be pregnant (measured via urinalysis).
- •Meet current abuse or dependence criteria for any substance other than nicotine or caffeine (measured via the SCID 5).
- •Produce a positive urine screen for drugs of abuse or alcohol at the fMRI scan visits.
- •Meet DSM-IV criteria for major depressive episode in the past six months, lifetime DSM-IV diagnosis of organic mental disorder, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder or psychotic disorders not elsewhere classified (measured via the SCID 5).
- •Be currently suicidal as assessed by DSM 5 and the Beck Depression Inventory.
- •Current use of medications or any history of a medical condition that might affect the central nervous system at the time of scanning including: Abnormal structural MRI, or a history of head trauma or injury causing loss of consciousness lasting longer than 3 minutes or associated with skull fracture or intracranial bleeding or who had irremovable magnetically active objects on or within their body, history of epilepsy, current use of a beta-blocker or prescription analgesic/anxiolytic. (assessed by self-report).
- •MRI exclusion criteria. (additional information outlined in the "protection of human subjects" section).
- •History of claustrophobia.
- •History of propylene glycol sensitivity/allergy.
研究组 & 干预措施
Dual nicotine patch and electronic cigarette
Nicotine patch and the electronic cigarette will be administered.
干预措施: Dual nicotine patch and electronic cigarette (Other)
结局指标
主要结局
Reduction in Cue Reactivity
时间窗: 2 weeks after use
Outcomes will be measured using a battery of self-report, neuroimagning, and behavioral measures of cue-reactivity.
次要结局
未报告次要终点
研究者
Scott Lukas
Professor of Psychiatry, HMS and Director, McLean Imaging Center
Mclean Hospital