Clinical Outcome of Patients With COVID-19 Pneumonia Treated With Corticosteroids and Colchicine in Colombia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 301
- 试验地点
- 1
- 主要终点
- Outcome
研究概览
简要总结
Cross sectional study of 301 adult patients with Covid-19 Pneumonia treated with corticosteroid and/or colchicine
详细描述
A cross sectional study of 301 adult patients with Covid-19 Pneumonia confirmed by Real-Time Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-CoV2), Berlin protocol, who required hospitalization in three hospitals in Antioquia, Colombia. Patients were treated according to the institutional protocol (from March 20, 2020 to June 30, 2020) with corticosteroid if the patient required supplemental oxygen. From July 1, 2020, the management protocol changed with the addition of colchicine to all patients admitted to the institutions. The treatment was supervised and monitored by the same specialist in infectology of the institutions.
We describe the clinical manifestations and outcomes of the patients who received these treatments. The patient's information was analyzed according to the outcome of interest (alive/dead) with univariate, bivariate, and multivariate measures to adjust the variables that presented statistical association.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The included patients were older than 18 years hospitalized for Covid-19 Pneumonia, confirmed positive by Real-Time Reverse Transcription Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-Cov2) by Berlin protocol. The samples were taken from a nasopharyngeal swab.
- •The patients should also have radiological confirmation of Pneumonia, mostly chest tomography or chest X-rays, to support the diagnosis of Covid-19 Pneumonia.
排除标准
- 未提供
研究组 & 干预措施
Steroids
Dexamethasone 6mg intravenous OD for seven to ten days
干预措施: Corticosteroid with or without colchicine (Drug)
Colchicine
Patients treated with colchicine at a dose of 0.5 mg every 12 hours for 7 to 14 days.
干预措施: Corticosteroid with or without colchicine (Drug)
结局指标
主要结局
Outcome
时间窗: March 20 to August 07, 2020
Dead or alive
次要结局
未报告次要终点
研究者
Miguel Alejandro Pinzón
Internal Medicine - Infectious Diseases Specialist
Clínica Medellín - Grupo Quirónsalud
