Effect of Non-surgical Periodontal Treatment on Renal Function and C-reactive Protein Levels in Hemodialysis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Disease Stage 5
- Sponsor
- Universidade Federal de Santa Maria
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- effect of periodontal treatment on levels of systemic inflammatory markers
- Last Updated
- 6 years ago
Overview
Brief Summary
The presence of periodontitis has been hypothesized as a risk factor for several systemic outcomes, including chronic kidney disease (CKD). Therefore, the aim of this study is to evaluate the impact of non-surgical periodontal treatment on CRP levels and quality of life of patients with chronic kidney disease undergoing hemodialysis (HD) in Santa Maria-RS.
Detailed Description
C-reactive protein (CRP) has been identified as a possible mediator of the association between periodontitis and various systemic diseases. The presence of periodontitis has been hypothesized as a risk factor for several systemic outcomes, including chronic kidney disease (CKD). Therefore, the aim of this study is to evaluate the impact of non-surgical periodontal treatment on CRP levels and quality of life of patients with chronic kidney disease undergoing hemodialysis (HD) in Santa Maria-RS. A total of 88 patients with severe periodontitis who are on HD therapy will be included in this study. At baseline, periodontal, radiographic, blood test, and quality-of-life questionnaire will be assessed for all patients, after which severe periodontitis will be defined according to the American Association of Periodontology and European Federation of Periodontology. The 88 patients with periodontal disease will be randomized and divided into two groups. One group will receive full mouth non-surgical periodontal treatment (TPNC) and a late treatment group that will receive TPNC only at the end of the study. All patients will receive follow-up of periodontal parameters and blood collection for initial CRP assessment at 3 and 6 months after treatment. Outcome evaluators will be blind to the group the patient belongs to. Patients in the immediate treatment group will receive follow-up oral hygiene instructions and use 0.12% chlorhexidine mouthwash during the first week after treatment.
Investigators
Fabricio Batistin Zanatta
Principal advisor
Universidade Federal de Santa Maria
Eligibility Criteria
Inclusion Criteria
- •Having been diagnosed with chronic kidney disease (CKD) for at least 90 days.
- •Have at least 8 teeth in the mouth.
- •For the patient to be classified as having periodontal disease, he must have at least two nonadjacent sites with insertion loss of 3mm or more and two nonadjacent sites with probing depth of 4mm or more.
Exclusion Criteria
- •Ineligible individuals were characterized by exhibiting one of the following conditions:
- •Patients diagnosed with malignant neoplasia;
- •Patients diagnosed with carriers of the HIV virus;
- •Pregnant or lactating women;
- •Patients with absence of all dental elements (total edentulous);
- •Patients undergoing orthodontic treatment;
- •Patients who have received periodontal treatment in the last 6 months.
- •Patients with active infection (other than periodontitis) who require antibiotic prophylaxis;
Outcomes
Primary Outcomes
effect of periodontal treatment on levels of systemic inflammatory markers
Time Frame: baseline changes by 6 months follow-up
To evaluate the impacts of periodontal treatment on the levels of systemic inflammatory markers such as C-reactive protein, albumin and transferrin saturation. The patients will be submitted to the collection of blood sample in the baseline, 3 and 6 months to obtain the clinical variables.
Secondary Outcomes
- effect of periodontal treatment on overall quality of life and related to kidney disease(baseline changes by 6 months follow-up)
- effect of periodontal treatment on overall quality of life(baseline changes by 6 months follow-up)
- effect of periodontal treatment on psychological condition in patients with chronic kidney disease undergoing hemodialysis(baseline changes by 6 months follow-up)
- effect of periodontal treatment on psychological condition(baseline changes by 6 months follow-up)
- effect of periodontal treatment on oral health-related quality of life(baseline changes by 6 months follow-up)