A study to see the effect of calcium and vitamin D supplementation on the progression of dengue fever to dengue shock syndrome and dengue hemorrhagic fever,

Recruiting

Conditions: Dengue fever [classical dengue]. Ayurveda Condition: DANDAKAHÂ (KEVALAVATA),

Registration Number: CTRI/2024/05/066756

Lead Sponsor: MILIND RAJ NAGVANSHI

Brief Summary: IT IS A RANDOMISED PLACEBO CONTROLLED STUDY EVALUATING THE EFFECT OF CALCIUM AND VITAMIN D SUPPLEMENTATION ON THE OUTCOME OF DENGUE FEVER . IT IS A PROSPECTIVE , DOUBLE BLINDED ,PLACEBO CONTROLLED SINGLE CENTRE RANDOMIZED CONTROL TRIAL

ALL RANDOMIZED ADMITTED PATIENTS OF DENGUE FEVER WILL BE PLACED EITHER ON ORAL CALCIUM 500MG BD FOR 15 DAYS OR ORAL CHOLECALCIFEROL4000 IU PER DAY FOR 15 DAYS FROM DATE OF ADMISSION ALONG WITH STANDARD THERAPY

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 120

Inclusion Criteria

Patient with acute dengue fever confirmed by lab investigations , all patients wiling to give informed consent, all acute dengue fever patient admitted to medicine wards /CCW/ICU at jnmch.

Exclusion Criteria

Age more than 60 yr and pregnant females, patient presenting with dengue shock syndrome and dengue hemorrhagic fever, diagnosed comorbid conditions like known case of Type2DM, syst HTN,cancer,active TB, hyperparathyroidism,hypothyroidism,osteoporosis,CKD,CLD,COPD,CAD,CARDIOMYOPATHY,MALABSORPTION,history of allergy from study medication, patients not giving consent for study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TO EVALUATE THE EFFECT OF CALCIUM AND VITAMIN D SUPPLEMENTATION ON ADMITTED ACUTE DENGUE FEVER PATIENT ON THEIR PROGRESSION TO DSS AND DHF	TO EVALUATE THE EFFECT OF CALCIUM AND VITAMIN D SUPPLEMENTATION ON ADMITTED ACUTE DENGUE FEVER PATIENT ON THEIR PROGRESSION TO DSS AND DHF

Secondary Outcome Measures

Name	Time	Method
Progressive worsening of thrombocytopenia,major and minor bleeding episodes,hepatopathy,hypocalcemia,shock,respiratory failure,acute kidney injury,cardiac arrhythmias,encephalopathy,capillary leakage	Progressive worsening of thrombocytopenia,major and minor bleeding episodes,hepatopathy,hypocalcemia,shock,respiratory failure,acute kidney injury,cardiac arrhythmias,encephalopathy,capillary leakage

Trial Locations

Locations (1): Jawaharlal Nehru medical college and hospital Aligarh Muslim University
🇮🇳
Aligarh, UTTAR PRADESH, India
Jawaharlal Nehru medical college and hospital Aligarh Muslim University
🇮🇳Aligarh, UTTAR PRADESH, India
Milind raj nagvanshi
Principal investigator
8419051230
milindrajnagvanshi@gmail.com