Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry

Active, not recruiting

• Conditions: Echocardiography; Heart Failure; Heart Failure Acute
• Interventions: Diagnostic Test: Echocardiography with speckle-tracking imaging

• Registration Number: NCT03513653
• Lead Sponsor: Seoul National University Hospital

Brief Summary

STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University Bundang Hospital, Seoul National University Hospital, and Chungnam National University Hospital) from January 2009 through December 2016.

Detailed Description

Patients with signs or symptoms of heart failure and either lung congestion, or objective findings of left ventricular (LV) systolic dysfunction or structural heart disease, were eligible for the study. Echocardiography was performed and both LV ejection fraction (LVEF) and LV global longitudinal strain (LV-GLS), right ventricular GLS (RV-GLS) were measured.

Study Timeline

• Study Start: 2009-01-01
• Primary Completion: 2017-09-05
• Study First Submitted: 2018-04-19
• Study First Submitted QC: 2018-04-30
• Study First Posted: 2018-05-01
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-11
• Last Update Posted: 2023-04-12
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 4312

Inclusion Criteria

• Patients with signs or symptoms of HF and either lung congestion, or objective findings of LV systolic dysfunction or structural heart disease

Exclusion Criteria

• Patients who presented with acute coronary syndrome

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acute heart failure	Echocardiography with speckle-tracking imaging	Patients hospitalized for acute heart failure and underwent echocardiography with speckle-tracking imaging

Primary Outcome Measures

Name	Time	Method
All-cause mortality	up to 5 years	Death from any cause

Secondary Outcome Measures

Name	Time	Method
Hospitalization for heart failure	up to 5 years	Any hospitalization for acute heart failure after the index hospitalization
Composite of all-cause mortality and hospitalization for heart failure	up to 5 years	Death from any cause or any hospitalization for acute heart failure after the index hospitalization
Ischemic stroke	up to 5 years	Ischemic stroke (an episode of neurological dysfunction caused by embolism) after the index hospitalization

Trial Locations

Locations (3)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of

Chungnam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of