Effects of Semaglutide vs Dulaglutide on Epicardial Adipose Tissue Thickness in Subjects With Type 2 Diabetes and Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Epicardial Fat thickness
研究概览
简要总结
Epicardial Fat (EAT), the visceral fat depot of the heart, is a modifiable cardio-metabolic risk factor and therapeutic target. EAT expresses GLP-1 receptors (GLP-1R). GLP-1 receptor agonist liraglutide is known to significantly decrease EAT thickness. However, the effects of GLP-1 receptor agonists semaglutide and dulaglutide on EAT thickness are unknown
详细描述
This is a retrospective, observational, case control study. Data were obtained from retrospective review of the electronic medical records.
Patients were treated with either semaglutide, dulaglutide or metformin as standard of care, during routine clinical practice, regardless of the study. Each patient underwent routine labs and an onsite ultrasound measurement of EAT thickness at baseline and at the routine 12-week follow up visit, as standard of care.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes,
- •BMI ≥27 kg/m2,
- •Age ≥ 18 years old
排除标准
- •Type 1 diabetes
- •Concurrent use of dipeptidyl peptidase 4 (DPP-4) inhibitors or other GLP-1 agonist receptors
- •History of diabetic ketoacidosis
- •Known contraindications to GLP-1 receptor agonists such as previous history of pancreatitis or medullary thyroid carcinoma, personal or family history of multiple endocrine neoplasia type 2
- •Acute infective diseases, cancer or chemotherapy
- •Use of systemic corticosteroids within the 3 months prior this study
- •Known or suspected allergy to semaglutide or dulaglutide excipients or related products
- •Pregnancy, breastfeeding or the intention of becoming pregnant
结局指标
主要结局
Epicardial Fat thickness
时间窗: 12 weeks
Ultrasound measured Epicardial Fat thickness
次要结局
未报告次要终点
研究者
Gianluca Iacobellis
Professor of Medicine
University of Miami