ISRCTN08336605已完成不适用
Efficacy and safety of albendazole and mebendazole as single-dose or in combination with ivermectin against soil-transmitted helminth infections, particularly Trichuris trichiura, in schoolchildren in Zanzibar, Tanzania: a randomised controlled trial
Swiss Tropical Institute (STI) (Switzerland)0 个研究点目标入组 2,000 人开始时间: 2009年2月24日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,000
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged greater than or equal to 5 years, both sexes
- •2. Submission of one stool sample of sufficient size to perform a total of two thick Kato-Katz smears at the baseline parasitological survey
- •3. Submission of one stool sample of sufficient size to perform a total of two thick Kato-Katz smears at the day of treatment
- •4. Infection with Trichuris trichiura as determined with the Kato-Katz method at the baseline survey. Additionally, also children with A. lumbricoides and/or hookworm infections will be included in one of the four treatment arms.
- •5. For females, not pregnant, as verbally assessed by medical personnel on the day of treatment
- •6. Absence of major systemic illnesses, as assessed by female medical personnel on the day of treatment
- •7. No anthelminthic treatment in the past 4 weeks, as verbally confirmed by the participant at the baseline survey
- •8. Written informed consent by the parent/legal guardian
排除标准
- •1. No stool sample given at baseline survey or day of treatment
- •2. No infection with T. trichiura, A. lumbricoides and/or hookworm at baseline
- •3. Subjects with fever or other signs of acute illness
- •4. Subjects with severe neurological disorder
- •5. Subjects with severe liver disorder
- •6. Pregnant schoolgirls
- •7. Recent history of anthelminthic treatment
- •8. Consent not given
研究者
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