Twin cohort for the study of (pre)clinical Inflammatory Bowel Disease in the NetherlandsThe TWIN-study
Recruiting
- Conditions
- Inflammatory Bowel Disease<br />IBD<br />M. Crohn<br />Crohn's disease<br />ziekte van Crohn<br />Ulcerative colitis<br />colitis ulcerosa<br />twin<br />tweeling<br />preklinisch<br />preclinical
- Registration Number
- NL-OMON23799
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 444
Inclusion Criteria
Inclusion criteria for IBD-discordant and IBD-concordant twins or multiples:
- Born as a sibling of, either a monozygous or dizygous, twin pair or multiplex
Exclusion Criteria
- No consent to participate in the study.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The association of the following factors with established and preclinical IBD will be studied:<br /><br>- Environmental factors <br /><br>- Early signs and symptoms of IBD development<br /><br>- Immunological phenotyping and function<br /><br>- Gut and oral microbiota anlayses<br /><br>- Metabolome analyses<br /><br>- Mucus barrier analyses<br /><br>- Epithelium analyses<br /><br>- DNA-sequencing analyses
- Secondary Outcome Measures
Name Time Method