Role of NLRP3 in Periodontitis and Diabetes
- Conditions
- Periodontal DiseasesMetabolic Disease
- Registration Number
- NCT04450810
- Lead Sponsor
- University of Messina
- Brief Summary
NLRP3 plays a key role in endothelial function and may be a link for the known interaction of periodontitis and diabetes. The investigators compared the impact of gingival health, periodontitis (CP), diabetes or of both diseases (CP +diabetes) on saliva and serum NLRP3levels.
- Detailed Description
The aim of this study was to evaluate a possible association between NLRP3 and gingival health, periodontitis (CP), diabetes or of both diseases (CP +diabetes) on saliva and serum NLRP3 levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 133
-
Presence of at least 15 teeth
-
CP with a minimum of 40% of sites with a clinical attachment level (CAL)
≥2mm and probing depth (PD) ≥4mm;
-
Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
-
Presence of ≥40% sites with bleeding on probing (BOP)
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical attachment level 1-year evaluation of changes in clinical attachment level
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Messina
🇮🇹Messina, Italy
University of Messina🇮🇹Messina, Italy