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Clinical Trials/ISRCTN37972669
ISRCTN37972669
Completed
Not Applicable

Preimplantation genetic screening on day 3 embryos using Comparative Genomic Hybridization (CGH)-array in women of advanced maternal age: a prospective randomised controlled trial

BlueGnome Ltd (UK)0 sites200 target enrollmentDecember 20, 2010
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ConditionsInfertilityPregnancy and ChildbirthFemale infertility

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Infertility
Sponsor
BlueGnome Ltd (UK)
Enrollment
200
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
December 20, 2010
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
Female

Investigators

Sponsor
BlueGnome Ltd (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Female patients aged between 36 and 43 years undergoing an in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) attempt at the GENERA centre for Reproductive Medicine in Rome
  • •2\. History of less than 3 consecutive miscarriages and no more than 2 failed IVF/ICSI cycles
  • •3\. Greater than or equal to 6 metaphase II (MII) oocytes retrieved
  • •4\. Signed consent form

Exclusion Criteria

  • •1\. Azoospermic male partner
  • •2\. Severe male factor infertility defined as ejaculate sperm of less than 1 million sperm/ml
  • •3\. Hydrosalpinx
  • •4\. Polycystic ovarian syndrome (PCOS)
  • •5\. Preimplantation genetic diagnosis (PGD) cycles for monogenic defects and/or chromosomal structural abnormalities
  • •6\. Female patients with pathological uterine cavity
  • •7\. Number of retrieved MII oocytes below 6
  • •8\. Known American Society for Reproductive Medicine (ASRM) Grade III or IV endometriosis
  • •9\. Maternal disease that is not clinically stable and known to impact the ability to become pregnant or carry a pregnancy to term
  • •9\.1\. Lupus

Outcomes

Primary Outcomes

Not specified

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