In-stent Restenosis and Pericoronary Fat Attenuation Index

Completed

• Conditions: In-stent Restenosis

• Registration Number: NCT05512832
• Lead Sponsor: RenJi Hospital

Brief Summary

This study aims to investigate the predictive value of fat attenuation index (FAI) and related radiomics characteristics of pericoronary fat in patients after percutaneous coronary intervention (PCI) for the occurrence of in-stent restenosis (ISR) during the follow-up period (9 to 24 months). The results of this study are expected to provide an early assessment of the inflammation around the coronary lesion segment in patients after PCI, and provide a basis for early targeted intensive drug therapy in clinical practice.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Primary Completion: 2022-06-30
• Status Verified: 2022-08
• Study Completion: 2022-08-15
• Study First Submitted: 2022-08-17
• Study First Submitted QC: 2022-08-21
• Last Update Submitted: 2022-08-21
• Study First Posted: 2022-08-23
• Last Update Posted: 2022-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• Patients with coronary heart disease who have undergone PCI;
• Patients followed up coronary angiography 9 to 24 months after PCI;
• Patients received chest CT examination during inpatient/outpatient follow-up;

Exclusion Criteria

• Patients with diseases of the immune system;
• Patients with history of tumor diseases;
• Patients with chronic/acute infectious diseases;
• Image quality is not sufficient for analysis;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fat attenuation index (FAI)	2022.8.15-2023.8.14	The pericoronary FAI was defined as the mean CT attenuation of the pericoronary adipose tissue (-190 to -30 HU). Peri-stent FAI was measured around the stent segment of all 3 major epicardial coronary vessels.

Trial Locations

Locations (1)

Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine; 🇨🇳 Shanghai, Shanghai, China