Influence of habitual dietary fibre intake on the responsiveness of the gut microbiota to a prebiotic

Not Applicable

Completed

• Conditions: Prevention of suboptimal diet related health conditions, i.e. obesity; Prevention of suboptimal diet related health conditions, i.e. diabetes; Prevention of suboptimal diet related health conditions, i.e. cancer; Prevention of suboptimal diet related health conditions, i.e. heart disease; Diet and Nutrition - Obesity; Metabolic and Endocrine - Diabetes; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12615000922572
• Lead Sponsor: Genelle Healey

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

The target population for recruitment are healthy male and female individuals between the age of 19 and 65 years with a BMI of between 18.5 and 30kg/m2. Individuals will need to have either a particularly low or high habitual dietary fibre intake to be considered eligible to participate in the study.

Exclusion Criteria

* Aged <19 or >65 years
* Taken antibiotics within the last 6 months
* Taken laxatives, gastric motility medications, prebiotic or probiotic containing foods or supplements within the last month
* Of poor health- cancer, gastrointestinal disorders (irritable bowel syndrome, inflammatory bowel disease, coeliac disease, constipation, diarrhoea, excessive bloating), autoimmune disorders, diabetes, heart disease, renal failure
* BMI <18.5 or >30kg/m2
* Significant weight loss or weight gain (>5%) within the past year
* Significant dietary change within the past year
* Pregnant, breastfeeding or planning a pregnancy
* Food intolerance which causes gastrointestinal symptoms (i.e. lactose intolerance, gluten sensitivity)
* Smokers
* High alcohol consumers

If a potential participant is only ineligible to participate in the study because they are taking prebiotic or probiotic containing foods or supplements they can become eligible for inclusion in the study if they are willing to discontinue these foods or supplements for a month prior to starting the study and during the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified