The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- The brain constructure and neural network changing one day after shunting
Study Overview
Brief Summary
With the advent of the aging society, dementia becomes the focus of common people. As for the neurodegeneration dementia, no disease modifying treatments have been discovered. Idiopathic normal pressure hydrocephalus (iNPH) is considered as one of reversible dementia, which can be hint by the surgery. In addition, dementia of iNPH is the typical subcortical dementia. Therefore exploring the pathogenic mechanism is conducive to the early diagnosis and treatment. This research is to monitor the changing of iNPHGS, cognitive function, walking ability as well as brain construction imaging and neural network before and after ventriculo-peritoneal shunting in order to demonstrate the pathogenesis of triads. In the process, the supplementary test, for instance, CSF tap test, will be validated the predictive value.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 50 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ncluded will be subjects with a probable diagnosis of NPH. The diagnosis will be based primarily on presence of gait impairment plus at least one other impairment in urinary symptoms, cognition impairment or both.
- •Are 50 years old or older
- •Patients who understand the study protocol
- •Patients who meet the criteria for NPH
- •A typical personal history
- •A typical brain imaging on head CT or MRI
- •Normal LP findings excluding other conditions
- •Exclusion of other conditions causing the symptomatology
Exclusion Criteria
- •Patients below the age of 50 years.
- •Patients who underwent shunt surgery before
Outcomes
Primary Outcomes
The brain constructure and neural network changing one day after shunting
Time Frame: Day 1 after shunting
* Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume * Neural network( DMN)by the resting functional MRI
The brain constructure and neural network changing one year after shunting
Time Frame: one year after shunting
Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI
The brain constructure and neural network changing 90 days after shunting
Time Frame: Day 90 after shunting
Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI
Secondary Outcomes
- Assessment of the clinical syndrome of normal pressure hydrocephalus(one year after shunting)