The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The brain constructure and neural network changing one day after shunting
研究概览
简要总结
With the advent of the aging society, dementia becomes the focus of common people. As for the neurodegeneration dementia, no disease modifying treatments have been discovered. Idiopathic normal pressure hydrocephalus (iNPH) is considered as one of reversible dementia, which can be hint by the surgery. In addition, dementia of iNPH is the typical subcortical dementia. Therefore exploring the pathogenic mechanism is conducive to the early diagnosis and treatment. This research is to monitor the changing of iNPHGS, cognitive function, walking ability as well as brain construction imaging and neural network before and after ventriculo-peritoneal shunting in order to demonstrate the pathogenesis of triads. In the process, the supplementary test, for instance, CSF tap test, will be validated the predictive value.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ncluded will be subjects with a probable diagnosis of NPH. The diagnosis will be based primarily on presence of gait impairment plus at least one other impairment in urinary symptoms, cognition impairment or both.
- •Are 50 years old or older
- •Patients who understand the study protocol
- •Patients who meet the criteria for NPH
- •A typical personal history
- •A typical brain imaging on head CT or MRI
- •Normal LP findings excluding other conditions
- •Exclusion of other conditions causing the symptomatology
排除标准
- •Patients below the age of 50 years.
- •Patients who underwent shunt surgery before
结局指标
主要结局
The brain constructure and neural network changing one day after shunting
时间窗: Day 1 after shunting
* Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume * Neural network( DMN)by the resting functional MRI
The brain constructure and neural network changing one year after shunting
时间窗: one year after shunting
Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI
The brain constructure and neural network changing 90 days after shunting
时间窗: Day 90 after shunting
Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI
次要结局
- Assessment of the clinical syndrome of normal pressure hydrocephalus(one year after shunting)