DRKS00018867尚未招募不适用
Functional Epigenomics of Sepsis - FUEGOS
Klinik für AnästhesiologieUniversitätsklinikum Heidelberg0 个研究点目标入组 250 人开始时间: 2019年11月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 250
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Patients with Sepsis:
- •Consent by the legal representative;
- •At least 2 SIRS criteria met:
- •- temperature <36ºC or> 38ºC
- •- tachycardia (> 90 /min)
- •- leukocytosis (> 12,000 /µl) OR leukopenia (<4,000 /µl) OR left shift (>10% immature blasts)
- •- Tachypnea (> 20 /min) OR paCO2 <32 mmHg OR oxygenation index (FiO2/paO2) <200 OR mechanical Ventilation;
- •Clinical or microbiological evidence of infection
- •Sepsis-associated organ dysfunction indicated by a change in the Sequential Organ Failure Assessment (SOFA) score by 2 or more points (compared to previous day)
- •Patients after surgery:
- •Informed consent;
- •Elective major surgery scheduled.
- •Healthy volunteers:
- •Informed consent.
排除标准
- •Common exclusion criteria of all study groups:
- •Inclusion in an interventional study;
- •infectious viral diseases (HBV, HCV, HIV);
- •Iatrogenic immunosuppression.
- •Specific exclusion criteria of patients with sepsis:
- •Diagnosis sepsis >24 h.
- •Specific exclusion criteria of healthy volunteers:
- •One of the following states during the last 7 days:
- •- Influenza infection or flu
- •- Sports injuries or other trauma
- •- Large-scale dental interventions (e.g., tooth extraction)
- •- Blood or platelet donation.
研究者
相似试验
招募中
不适用
Epigenetic Mechanisms in SepsisR65.9R65.1SepsisSystemic Inflammatory Response Syndrome of infectious origin with organ failureSystemic Inflammatory Response Syndrome, unspecifiedDRKS00011667niversitätsklinikum Heidelberg20
招募中
Unknown
Identifying Novel Sepsis EndotypesSepsisJPRN-UMIN000049747Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine1,000
撤回
不适用
Identifying new biomarkers for sepsis diagnosis with proteomics techniquesinfection10019815sepsisNL-OMON32062niversitair Medisch Centrum Utrecht15
已完成
不适用
Biomarkers of Sepsisblood poisoning10002252sepsisNL-OMON36012niversitair Medisch Centrum Utrecht500
撤回
不适用
Biomarkers of Sepsisblood poisoning10002252sepsisNL-OMON36119niversitair Medisch Centrum Utrecht500