Evaluation of efficacy of magnesium sulphate as an adjuvant to lignocaine in inferior alveolar nerve block for extraction of mandibular third molar.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- 1) duration of action
研究概览
简要总结
To assess the effect of combination of lignocaine (1:200000) and magnesium sulphate on
-
1) Duration of action
-
2) Pain perception
-
3) Burning sensation on injection
Several additives have been combined with local anaesthetics to improve block quality and post-operative analgesia. Magnesium sulphate is one potential additive. Based on previous clinical trials, magnesium sulphate has promising results and has been known to increase the duration of blocks. This additive, if successful can also decrease the number of injections required to achieve clinical levels of local anesthesia.
Patients with mandibular impacted third molars requiring trans-alveolar extraction on both right and left side (bilateral extraction). The left side of the patient will be considered as the control site where only lignocaine (1,200,000) will be injected whereas the right side will act as the test side where lignocaine(1:200,000) with magnesium sulphate will be injected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients who require extraction of mandibular third molars on both left and right side.
排除标准
- •Patients younger than 18 years of age, pregnant, lactating, and significant medical comorbidities (ASA III or more), history of allergy to LA will be excluded from the study.
结局指标
主要结局
1) duration of action
时间窗: 1) effect of local anesthesia 4 hours after injection of anesthetic
次要结局
- 1) Pain perception(2) burning sensation on injection)