Effectiveness of local anesthesia with added magnesium sulphate for lower wisdom teeth extraction

Not yet recruiting

• Conditions: Bilateral impacted mandibular third molars

• Registration Number: CTRI/2018/05/013842
• Lead Sponsor: Dr Srikanth G

Brief Summary

To assess the effect of combination of lignocaine (1:200000) and magnesium sulphate on

- 1)      Duration of action



- 2)      Pain perception



- 3)      Burning sensation on injection

Several additives have been combined with local anaesthetics to improve block quality and post-operative analgesia. Magnesium sulphate is one potential additive. Based on previous clinical trials, magnesium sulphate has promising results and has been known to increase the duration of blocks. This additive, if successful can also decrease the number of injections required to achieve clinical levels of local anesthesia.

Patients with mandibular impacted third molars requiring trans-alveolar extraction on both right and left side (bilateral extraction). The left side of the patient will be considered as the control site where only lignocaine (1,200,000) will be injected whereas the right side will act as the test side where lignocaine(1:200,000)  with magnesium sulphate will be injected.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-21
• Last Update Posted: 2018-10-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients who require extraction of mandibular third molars on both left and right side.

Exclusion Criteria

Patients younger than 18 years of age, pregnant, lactating, and significant medical comorbidities (ASA III or more), history of allergy to LA will be excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) duration of action	1) effect of local anesthesia 4 hours after injection of anesthetic

Secondary Outcome Measures

Name	Time	Method
1) Pain perception	2) burning sensation on injection

Trial Locations

Locations (1)

Manipal College of Dental sciences, Manipal; 🇮🇳 Udupi, KARNATAKA, India

Manipal College of Dental sciences, Manipal

🇮🇳Udupi, KARNATAKA, India

Mrinal Ranjan

Principal investigator

9986937286

mrinal.ranjan18@gmail.com